College Football Week 15 Top 25 Picks, Odds, Box Score Predictions, Rankings, Schedule

The Big Ten Championship Game is the feature game of conference championship weekend.

The top-ranked Ohio State Buckeyes square off against the No. 2 Indiana Hoosiers in a contest that will decide the top seed in the College Football Playoff and likely the Heisman Trophy.

Ohio State and Indiana have not faced many challenges throughout the regular season, so Saturday's clash in Indianapolis will be a great test for both programs with the playoff around the corner.

The stakes are higher in the SEC Championship Game. The Alabama Crimson Tide need a win to ensure their safety in the 12-team playoff field.

Alabama's had the upper hand in the rivalry with the Georgia Bulldogs. UGA has plenty to play for as well with a first-round bye in the playoff in sight.

Week 15 AP Top 25 Schedule and Odds

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Odds via DraftKings Sportsbook.

Friday, December 5

Troy at No. 19 James Madison (-22.5) (7 p.m. ET, ESPN)

No. 20 North Texas (-2.5) at No. 21 Tulane (8 p.m. ET, ABC)

Saturday, December 6

No. 11 BYU vs. No. 5 Texas Tech (-13.5) (Noon ET, ABC)

No. 3 Georgia (-2.5) vs. No. 10 Alabama (4 p.m. ET, ABC)

No. 2 Indiana vs. No. 1 Ohio State (-5.5) (8 p.m. ET, Fox)

Duke vs. No. 16 Virginia (-3) (8 p.m. ET, ABC)

No. 2 Indiana vs. No. 1 Ohio State (-5.5)

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Indiana and Ohio State have been together at the top of the rankings for the last six weeks.

Both teams look like unstoppable machines, but in the eyes of the oddsmakers, Ohio State is the better team.

The Buckeyes are a 5.5-point favorite at a neutral site, which speaks volumes to how valued they are compared to the rest of the programs in college football.

Each team looked spectacular on the offensive end throughout Big Ten play, but defense should be the X-factor on Saturday.

Ohio State's defense held every opponent to 16 points or fewer and it limited eight opponents to single-digit point totals.

Indiana likely will score more than 10 points, but it will be hard for Fernando Mendoza and the Hoosiers to score in abundance, like they have for most of Big Ten play.

The Hoosiers defense is no slouch either. That unit allowed 10 points over the last two weeks and held five teams to single-digit point totals.

However, Indiana conceded 20 points to the Oregon Ducks in its toughest game on the calendar. The Hoosiers won that game, but the Ducks were able to move the ball.

The Julian Sayin-led Buckeyes offense could do the same against Oregon, especially if the wide receiver duo of Jeremiah Smith and Carnell Tate are healthier than they have been.

Ohio State has the more talented set of pass-catchers. That could be helpful for the Buckeyes in a game featuring two tough defenses.

If OSU's passing attack breaks through the IU defense, Sayin will be able to make one final case for the Heisman against one of his top competitors in Mendoza.

Prediction: Ohio State (-5.5)

No. 3 Georgia (-2.5) vs. No. 10 Alabama

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Georgia has an Alabama problem.

The Bulldogs have one win against the Crimson Tide across the last 11 meetings dating back to 2008.

Alabama's key to success in the last two years has been fast starts powered by Jalen Milroe in 2024 and Ty Simpson in 2025.

It is imperative for Georgia to come out of the first quarter with the lead, or tied, so that it doesn't have to chase the game, like it has in the last two meetings.

To UGA's credit, it made both of those contests competitive, but it didn't have enough juice to complete the full comeback.

Alabama shouldn't have to change much in its approach against Georgia, but it is worth noting that the Crimson Tide will be playing with far more pressure than the Bulldogs.

Alabama currently resides in the last at-large spot for the CFB Playoff, but it could drop out of the field with a loss in Atlanta.

Georgia is safely in the playoff field and is playing to land one of the four first-round byes.

A tighter Crimson Tide team could help UGA get out of the gates, and if that happens, the Bulldogs can win on a level playing field across the next three quarters. After all, they showed they can thrive in the head-to-head matchup after their horrendous starts.

Prediction: Georgia (-2.5)

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