Week 3 NFL Odds, Early Locks and Best Bets on the Schedule

Week 2 brought nearly as many surprises as the opening week of the 2025 NFL season did. Unfortunately, it brought a slew of injuries that could impact the remainder of the year and will impact Week 3.

Quarterbacks Justin Fields (concussion), Jayden Daniels (knee) and Joe Burrow (toe) were all injured over the weekend. Burrow is expected to miss "at least" three months following surgery, according to NFL Network's Ian Rapoport.

There's plenty of uncertainty surrounding the NFL landscape heading into Week 3, but what we've seen so far—along with projected matchups and past trends—can help expose some of the early best bets of the week.

*Lines via DraftKings Sportsbook

Colts -3 at Titans

AP Photo/Darron Cummings

Colts QB Daniel Jones

The Indianapolis Colts narrowly won in Week 2 and probably should have lost. Spencer Shrader missed a potential walk-off field goal as time expired but was bailed out by a defensive leveraging penalty. His second attempt was successful and gave Indy the win.

Now, the Colts are set to go on the road to face a division rival. In years past, this would have been a perfect opportunity to bet against the Colts and back a home dog.

This year, though, things are different. Quarterback Daniel Jones has given life to the Colts' offense, while new defensive coordinator Lou Anarumo has revitalized things on the other side of the ball.

The Tennessee Titans' defense is good enough to give Indy a tricky road test. However, rookie quarterback Cam Ward is playing behind one of the worst offensive lines in football, which sets the stage for Anarumo to wreak havoc.

This may be another close one for the Colts, but Indianapolis should win by at least a field goal.

Falcons -4.5 at Panthers

AP Photo/Danny Karnik

Falcons RB Bijan Robinson

The Atlanta Falcons made a fairly strong statement on Monday night by going into Minnesota and routing the Vikings in a 22-6 contest. Granted, Vikings quarterback J.J. McCarthy was making his second career start behind a patchwork offensive line, but there was a lot to like about the Falcons' performance.

Michael Penix Jr. played wonderfully, as did Bijan Robinson and the ground game. Atlanta's new-look pass rush also got going after making too few plays in Week 1.

Like the Colts, the Falcons will be on the road against a division foe in Week 3. If Atlanta can't beat the Carolina Panthers by at least a touchdown, though, something has gone awry.

Carolina has not looked good for the better part of eight quarters. A late rally against a suspect Arizona Cardinals defense in Week 2 is likely responsible for this relatively small line.

Three late touchdowns allowed the Panthers to make things close on Sunday, but they really should never have had the opportunity. Kyler Murray's ill-advised fourth-quarter interception in the red zone, however, opened the door for the backdoor cover. The Falcons shouldn't make a similar mistake.

Chiefs -5.5 at Giants

AP Photo/Reed Hoffmann

Chiefs QB Patrick Mahomes

There's no getting around the fact that a lackluster offense has led to the Kansas City Chiefs' 0-2 start. Outside of the occasional wow play from Patrick Mahomes, the Chiefs haven't put much on tape to feel good about.

Now, the Chiefs will go on the road to face a New York Giants team that just dropped 37 points on the Dallas Cowboys.

However, now's as good a time as any to jump on the Chiefs as road favorites. Yes, Russell Wilson and the Giants offense looked good on Sunday. New York's defense, though, did not—and neither did the defense of the Dallas Cowboys, for the second straight week.

Kansas City's defense did play extremely well in Week 2 after a rocky start to the season in Brazil. Wilson and the Giants are likely to perform more like they did in Week 1 (a 21-6 loss) than they did in Dallas.

This is a must-win game for the defending AFC champs, and that should give the Chiefs the focus and drive needed to produce a convincing road win.

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