College Football Picks Week 4: B/R's Expert Predictions for Top 5 Games

The cupcake games are largely over, and as we roll into conference play in college football, several teams have chances to pull off big-time upsets.

Clemson will travel to Tallahassee to face the defending national champion Florida State Seminoles, who will be without Jameis Winston for half of the game.

The FSU quarterback was suspended for the first half after he yelled an obscene phrase in public. Backup Sean Maguire will start in his place.

Alabama will play host to Florida. While the Tide will be challenged by a stout Florida defense, the big question here is whether the Gators offense can get things going on the road. Winning in Tuscaloosa is no easy task these days.

Clint Trickett has been exceeding expectations at quarterback for West Virginia, and he'll look to give Oklahoma all it can handle in the Sooners' first conference road test of the season.

Miami and Nebraska have a great history of epic clashes, and their prime-time showdown is sure to keep fans on the edge of their seats.

The final game our experts will pick pits an underrated Mississippi State team aiming to assert itself in the SEC against an LSU squad out to show it deserves to be mentioned among the elite.

Bleacher Report Media Lab

Ben Kercheval took a commanding lead after a wild Week 3, but as last week showed, anything can happen in college football.

Who will come out on top this weekend? Let us know your picks in the comments below.

Bleacher Report Media Lab

*All picks made straight up. Spread is not a factor.