Patrick Mahomes and Tom Brady will square off for the sixth time in their careers in Week 4 of the 2022 NFL season.
The NFL announced Thursday that the Kansas City Chiefs will play the Tampa Bay Buccaneers at Raymond James Stadium in Week 4 on Sunday Night Football.
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In anticipation of the full schedule being released Thursday at 8 p.m. ET, the NFL has been giving fans a taste of what to expect. The league has announced 11 games, including the Chiefs-Bucs matchup.
Other notable games that have been announced include the Chiefs hosting the Los Angeles Chargers in the first Thursday night game on Amazon Prime, as well as two Monday night games in Week 2 featuring the Tennessee Titans vs. Buffalo Bills and Minnesota Vikings vs. Philadelphia Eagles.
The latter game will mark the first Monday night game on ABC since the 2005 season.
Several other games have been reported, but the league has not confirmed them.
Brady is 3-2 against Mahomes. Their most recent meeting came in Super Bowl LV as the Bucs defeated the Chiefs 31-9 in arguably the worst game of Mahomes' career. He finished 26-of-49 for 270 yards with no touchdowns and two interceptions.
Tampa Bay's defense sacked Mahomes three times and hit him nine times. It's one of only two games in his career in which he's thrown multiple interceptions without a touchdown pass.
Their first two meetings came during the 2018 season when Brady was still with the New England Patriots and Mahomes was in his first year as Kansas City's starting quarterback.
The Patriots beat the Chiefs 43-40 in Week 6. The game featured three lead changes in the fourth quarter. Mahomes' 75-yard touchdown pass to Tyreek Hill with 3:03 remaining tied the score at 40. Brady drove the Patriots down the field in six plays to set up Stephen Gostkowski's 28-yard game-winning field goal as time expired.
In the rematch in the AFC Championship Game, the two teams combined to score 24 points in the final 3:32 of regulation to send the game to overtime.
The Patriots won the coin toss to start overtime and put together a 13-play drive, capped off by Rex Burkhead's two-yard touchdown run for a 37-31 win. They went on to defeat the Los Angeles Rams in Super Bowl LIII for Brady's sixth title with New England.
Mahomes and the Chiefs won their next two games against Brady. They defeated the Patriots, 23-16, in Week 14 of the 2019 season.
Kansas City held on for a 27-24 win over the Buccaneers in Week 12 of the 2020 season. Mahomes threw for 462 yards and three touchdowns in the game. It was the final loss of the year for Brady and Tampa Bay.
The Bucs came out of their bye the following week and went on an eight-game winning streak, capped off by the Super Bowl victory over Kansas City.
This season's Chiefs-Bucs game will be played Oct. 2.