NFL Week 6 Predictions: Projections for the Early Lines, Spreads and Odds

Although the Minnesota Vikings couldn't hand the Seattle Seahawks their first loss of the season on Sunday night (they fell 27-26 and came up just short), there were some notable upsets in the NFL in Week 5. And none were bigger than the Las Vegas Raiders' road win over the Kansas City Chiefs.

The Chiefs suffered their first loss of the season, falling 40-32, which leaves five undefeated teams in the league: the Seahawks (5-0), Buffalo Bills (4-0), Green Bay Packers (4-0), Pittsburgh Steelers (4-0) and Tennessee Titans (3-0).

There will only be four by the end of Week 5, though, as the Bills and Titans are set to face off Tuesday night.

By next week, perhaps there will be even fewer unbeaten teams remaining, as upsets are always possible in the NFL, as evidenced by some of Sunday's surprising results.

Here's an early look at the Week 6 schedule, along with available odds and predictions for each matchup.

Week 6 Odds, Predictions

Sunday, Oct. 18

Houston Texans at Tennessee Titans (no line), 1 p.m. ET

Cincinnati Bengals at Indianapolis Colts (-9), 1 p.m. ET

Atlanta Falcons at Minnesota Vikings (no line), 1 p.m. ET

Denver Broncos at New England Patriots (no line), 1 p.m. ET

Washington Football Team at New York Giants (-3.5), 1 p.m. ET

Baltimore Ravens (-7.5) at Philadelphia Eagles, 1 p.m. ET

Cleveland Browns at Pittsburgh Steelers (-4), 1 p.m. ET

Chicago Bears at Carolina Panthers (-3), 1 p.m. ET

Detroit Lions (-3) at Jacksonville Jaguars, 1 p.m. ET

New York Jets at Miami Dolphins (no line), 4:05 p.m. ET

Green Bay Packers (-1.5) at Tampa Bay Buccaneers, 4:25 p.m. ET

Los Angeles Rams (-3) at San Francisco 49ers, 8:20 p.m. ET

Monday, Oct. 19

Kansas City Chiefs at Buffalo Bills (no line), 5 p.m. ET

Arizona Cardinals (-2.5) at Dallas Cowboys, 8:15 p.m. ET

Odds obtained via DraftKings. Picks in bold against the spread.

Potential Upsets to Consider

Cleveland Browns (+4) at Pittsburgh Steelers

Although the Steelers are undefeated, the Browns are playing at a high level since their season-opening road loss to the Ravens.

Since that 38-6 defeat at Baltimore, Cleveland has notched four straight wins over Cincinnati, Washington, Dallas and Indianapolis. And Sunday's 32-23 win over the Colts may have been its most impressive yet.

Not only did Cleveland put up 385 total yards against one of the league's top defenses, but its own defense made some big plays as well. That included Ronnie Harrison Jr.'s 47-yard interception return touchdown early in the third quarter that put the Browns ahead 27-10.

Even if Cleveland loses at Pittsburgh in Week 6, this early four-point line is large enough to consider even if you don't have faith in the Browns pulling off the road win. The Steelers haven't faced much tough competition yet, as their four wins have come against teams with a combined record of 3-15-1.

And while Pittsburgh has a strong defense, so did Indianapolis, and that didn't stop Cleveland from improving to 4-1 with a win. So don't count out betting on the Browns again in Week 6.

Tampa Bay Buccaneers (+1.5) vs. Green Bay Packers

Kamil Krzaczynski/Associated Press

If the Buccaneers lose again in Week 6, they'll fall to 3-3. And that's not the type of record usually associated with a team led by Tom Brady.

This past Thursday, Tampa Bay's three-game winning streak came to an end when it fell 20-19 at Chicago. The veteran quarterback failed to lead a game-winning drive, as the Bucs turned the ball over on downs with 33 seconds remaining. And despite jumping out to a 13-0 lead, Tampa Bay couldn't put Chicago away and even trailed by one point at halftime.

The Buccaneers' offense has been dealing with injuries as wide receiver Chris Godwin (hamstring) and running backs Leonard Fournette (ankle) and LeSean McCoy (ankle) didn't play in Week 5. Wide receivers Mike Evans (ankle) and Scotty Miller (hip/groin) have also been banged up, although both played against the Bears. Once Tampa Bay gets healthier, it wouldn't be surprising to see it start stringing together wins again.

At 4-0, the Packers are going to be a tough opponent, and it's quite possible they'll remain undefeated with a win over the Bucs. But never count out Brady. And this Tampa Bay team is talented despite its 3-2 record, so it may be worth betting on the Buccaneers to bounce back with a statement win.

Dallas Cowboys (+2.5) vs. Arizona Cardinals

Michael Ainsworth/Associated Press

This line was likely heavily impacted by the Cowboys' loss of quarterback Dak Prescott, who underwent surgery on his right ankle on Sunday after leaving their win against the Giants in the third quarter.

According to ESPN's Todd Archer, the 27-year-old will need four-to-six months to recover, which leaves Andy Dalton to lead Dallas' offense moving forward.

Prescott is the better quarterback, but don't count out the Cowboys with the veteran backup at the helm. They'll still have talented playmakers around the 32-year-old, such as running back Ezekiel Elliott and numerous strong receivers, and they still found a way to pull out a 37-34 win on Sunday (although it was against the 0-5 Giants).

The Cardinals ended their two-game losing skid on Sunday, but that was expected with them taking on the 0-5 Jets.

Arizona had lost back-to-back games to Detroit and Carolina in Weeks 3 and 4, and Monday night's game will be its third straight road contest. So while the Cardinals are a 2.5-point favorite against the Cowboys, they're far from a sure thing.

If Dalton can play well in Dallas' offense and help it keep up with Arizona's high-scoring attack (which could put up big numbers against the Cowboys defense), then it's possible it will notch the home win, or at least lose by less than three points in a competitive game.