According to ESPN's Adam Schefter, the Broncos hope Lindsay's case is "mild," but his status is "in question."
Lindsay carried the ball seven times for 24 yards and made one catch for 11 yards before exiting the contest. Free-agent acquisition Melvin Gordon III took nearly all of the snaps at running back in the second half with Lindsay out.
Lindsay has been a revelation for the Broncos since they signed him as an undrafted free agent out of Colorado in 2018.
As a rookie, he started only eight of the 15 games he appeared in, but he still finished with 1,037 yards and nine touchdowns on the ground to go with 35 receptions for 241 yards and one score. The 26-year-old followed that with 1,011 rushing yards and seven rushing scores last season, as well as 35 grabs for 196 yards.
Despite Lindsay's success, the Broncos beefed up their backfield during the offseason by signing Gordon to a two-year, $16 million contract.
Gordon spent the first five years of his career with the Los Angeles Chargers. He reached the 1,000-yard rushing mark only once but scored 47 total touchdowns and was named to the Pro Bowl twice.
With Gordon leading the running game for much of Monday's game, the Broncos didn't seem to miss a beat. He finished with 78 yards and one touchdown on 15 carries, and he caught three passes for eight yards.
Gordon will be the clear bell-cow back if Lindsay misses time, while 2018 third-round pick Royce Freeman should slide into the backup role. Freeman had one carry and one reception in Monday's loss.
The Broncos will be back in action Sunday when they travel to Pittsburgh to take on the Steelers in Week 2.