As Jenna Laine of ESPN reported, Godwin was carted off the field after suffering his injury.
The third-year player had five catches for 121 receiving yards before leaving the game.
The injury leaves the Buccaneers extremely short-handed at receiver after Mike Evans left Week 14 with his own hamstring issue. Per Ian Rapoport of NFL Network, Evans is out for the year, although he hasn't yet been placed on injured reserve.
The duo had been arguably the best in football in 2019, ranking second and third in receiving yards entering the week behind only New Orleans Saints star Michael Thomas.
Godwin was in the midst of a breakout year with 86 catches for 1,333 yards and nine touchdowns through Week 15, all career highs.
With him on the sidelines, the Buccaneers are left with Breshad Perriman as the No. 1 option, although he had two first-half touchdowns Sunday. Scotty Miller also had his first career touchdown against the Lions.
It showed quarterback Jameis Winston can continue to produce regardless of who is catching passes down the field despite his well-known issues with turnovers.