NFL Predictions Week 4: Picks Guide, Odds Advice and Schedule Info

It will be tough to top Week 3, which brought us the Cleveland Browns' first win in almost two years and a historic upset by the Buffalo Bills, but Week 4 brings us another exciting slate of games around the NFL.

Eleven of the 14 games on the schedule feature a spread under a touchdown, which means we should be in store for some fun matchups that go down to the wire.

To prepare you for Sunday's action, here's a rundown of the schedule, followed by a breakdown of a few key games. Predicted winners against the spread are in bold.

Week 4 Matchups

Eagles (-3.5) at Titans

Bills at Packers (-9.5)

Lions at Cowboys (-3)

Buccaneers at Bears (-3)

Jets at Jaguars (-7.5)

Dolphins at Patriots (-7)

Texans at Colts (-1)

Seahawks (-3) at Cardinals

Bengals at Falcons (-4)

Browns at Raiders (-3)

49ers at Chargers (-10.5)

Saints (-3.5) at Giants

Ravens at Steelers (-3)

Chiefs (-4.5) at Broncos

Spreads according to OddsShark.

Buffalo Bills at Green Bay Packers (-9.5)

Hannah Foslien/Getty Images

After watching the Minnesota Vikings underestimate the Buffalo Bills in Week 3, the Green Bay Packers are unlikely to make the same mistake.

Minnesota shut out the Bills in the second half, but after falling behind 27-0, there just wasn't enough time for a comeback. It's likely that outcome was influenced by Minnesota's failure to take Buffalo seriously enough after watching the Bills stumble through their two games.

The Bills are also unlikely to have as much luck against the Packers as they did in Minnesota. Thanks to some costly turnovers that gave the Bills short fields to work with, Buffalo managed to reach 27 points despite racking up just 292 yards of total offense. To put that into perspective, of the 179 teams held under 300 yards of offense in 2017, only 10 scored 27 or more points.

Perhaps Buffalo will shock the world again and we will have to reconsider how we view the Bills, but until then, it's best to trust their performances from the first two gameweeks. A focused Packers team in search of their second win should cruise to victory.

Prediction: Packers 31, Bills 17

Detroit Lions at Dallas Cowboys (-3)

Abbie Parr/Getty Images

The Detroit Lions defense is far from elite, but a unit that just held Tom Brady and the New England Patriots to 10 points won't be intimated by the Dallas Cowboys' sputtering offense.

The Cowboys offense has scored on just 24.2 percent of its possessions, the second-worst rate in the NFL.

Dallas continues to run the ball reasonably well with Ezekiel Elliott; they have the league's sixth-ranked rushing offense, but that skill set doesn't matter as much anymore if you can't build an early lead with the passing game. And the Cowboys' 31st-ranked passing offense simply hasn't proved capable of building a lead to turn over to Elliott.

The Lions defense has some flaws—Detroit has already allowed two 100-yard rushers this season—but it also boasts the league's No. 1-ranked passing defense, led by cornerback Darius Slay.

Based on the strengths and weaknesses of each team, expect Dallas to be able to run the ball and control the clock to keep this one close. But in a close game in the NFL, the safe bet is to roll with the quarterback you trust. And in this case, that's Matthew Stafford.

Prediction: Lions 20, Cowboys 17

Seattle Seahawks (-3) at Arizona Cardinals

Ralph Freso/Associated Press

This is the most surprising spread of the week, because the Arizona Cardinals' performance this season does not deserve this much respect. Arizona has scored just 20 combined points through three games, less than half the scoring output of the next-worst team (Cowboys, 41 points).

However, rookie quarterback Josh Rosen is stepping in for Sam Bradford, and the oddsmakers are apparently expecting Rosen to give the Cardinals offense a pulse. 

Rosen has a bright future and will likely turn things around in Arizona eventually. Given the supporting cast around him, however, it's hard to imagine things getting better with a rookie taking snaps. 

According to Pro Football Focus' Sam Monson, the Cardinals offensive line is playing at a historically incompetent pace:

The Seattle Seahawks may not have the same dominant defense that led them to a couple Super Bowl appearances under Pete Carroll, but this unit should still be able to handle a rookie quarterback who is playing behind the league's worst offensive line.

Prediction: Seahawks 24, Cardinals 13