On Tuesday, ESPN's Adam Schefter reported Hargreaves will get a second opinion from Dr. James Andrews on the injury. Ian Rapoport of NFL Network reported the corner will be placed on injured reserve Wednesday.
Hargreaves had seven tackles and a forced fumble in Week 1.
The 23-year-old is coming off a disappointing 2017 season in which a hamstring injury ended his year after nine games. He finished with 42 combined tackles and five passes defended.
Although Hargreaves' season-ending injury didn't help matters, he had a role in the Buccaneers finishing dead last in defensive efficiency, per Football Outsiders. Tampa Bay also allowed more passing yards (260.6 per game) than any other team in the NFL.
As a result, the Bucs used a pair of second-round picks to get MJ Stewart and Carlton Davis in the 2018 draft. The team also re-signed Brent Grimes on a one-year, $10 million contract.
If anything, Hargreaves' latest injury may impact him more than Tampa Bay. His absence will open the door for either Stewart or Davis to potentially play himself into the first team.