NFL Week 6 Picks: Game-by-Game over-Under Predictions

Another weekend of NFL action is on the cards as Week 6 looms, and it features a bevy of lines worth taking a second look at.

With six unbeaten teams taking to the gridiron across the 14-game slate, it's not surprising to see a handful of spreads with a touchdown-or-more differential. While spreads always generate the most interest, it's the over-under lines that truly jump off the page in a number of Week 6 matchups.

Let's take a look at Week 6 predictions, fit with over-under lines and a closer breakdown of a few matchups.

NFL Week 6 Odds, Over-Under Predictions

Game	Odds	O/U	Final Projection
Atlanta at New Orleans	ATL -3	51.5	Falcons 24-17
Cincinnati at Buffalo	CIN -1	42	Bengals 28-17
Denver at Cleveland	DEN -3.5	42	Broncos 31-20
Chicago at Detroit	DET -2.5	42.5	Bears 24-21
Houston at Jacksonville	Even	43.5	Jaguars 20-17
Kansas City at Minnesota	MIN -4.5	44	Vikings 23-20
Washington at N.Y. Jets	NYJ -5.5	40.5	Jets 17-14
Arizona at Pittsburgh	ARI -3.5	44	Cardinals 31-14
Miami at Tennessee	TEN -2.5	43.5	Titans 20-17
Carolina at Seattle	SEA -5.5	41	Seahawks 24-20
San Diego at Green Bay	GB -9.5	50.5	Packers 38-20
Baltimore at San Francisco	BAL -2	44	Ravens 24-23
New England at Indianapolis	NE -7	55	Patriots 31-25
N.Y. Giants at Philadelphia	PHI -3.5	50	Giants 28-24

Odds courtesy of Odds Shark.

Miami Dolphins at Tennessee Titans (O/U 43.5)

Alan Diaz/Associated Press

If there's a favorable scenario to deal with a midseason coaching change (and there isn't), it's pulling the trigger at the start of a bye week and facing a struggling team in the very next game. That's what is on tap for the Miami Dolphins this weekend.

After firing Joe Philbin following an embarrassing 27-14 loss to the Jets in London, the Dolphins have been breaking in interim coach Dan Campbell and trying to rid themselves of the negativity of a 1-3 start. It sounds like he's having to start from scratch, however, as starting tackle Ja'Wuan James told Sun Sentinel's Omar Kelly:

"He had us watch all the bad plays we've had and really hone in on what you want to work on fundamentally," said James. "We ran through all the runs we had and he said 'I want you to be critical.'"

As a team that is really going back to square one, the Dolphins are bound to struggle with a visit to the Tennessee Titans. They may be on a three-game losing streak, but they've blown leads in their last two outings to Indianapolis and Buffalo and will be intent on proving themselves as the team's Twitter accounted:

Also on tap in this matchup are two defenses with plenty of potential, who should emerge to make this a low-scoring affair. Tennessee's defense held Buffalo to just 209 total yards last weekend and 80 came on a single drive, while Ndamukong Suh and the Dolphins are playing for their pride at this point.

Add that to two struggling offenses, and you have the obvious choice of taking the under.

Prediction: Titans 20, Dolphins 17

New York Giants at Philadelphia Eagles (O/U 50)

Seth Wenig/Associated Press

With the Dallas Cowboys scraping the bottom of the barrel roster-wise and suffering season-destructing injuries, this matchup between NFC East rivals on Monday Night Football feels like the closest thing we'll have to a midseason title game in the division.

Who would have thought after two weeks of the season that the Eagles and Giants would be in this spot? Both squads started out a lowly 0-2, and the Eagles added a third loss to Washington before dominating New Orleans over the weekend.

As for the Giants, they're riding high on momentum after a late touchdown drive against the 49ers by Eli Manning last Sunday night. His last completion, a game-winning touchdown to tight end Larry Donnell, set a franchise record, per ESPN Stats & Info:

Manning has proved to be worth virtually every penny of his massive extension signed in the offseason, and he's scorching defenses with or without Odell Beckham Jr. The star receiver missed a heavy portion of Sunday night's game, but he's "optimistic" to play next week, per Jordan Raanan of NJ.com.

The Eagles have gotten it together on offense as well after a treacherous start, hanging 39 points on the Saints and seeing the defense allow the Redskins' late victory. Sam Bradford is truly settling in, and DeMarco Murray is finally adding a dimension on the ground that should coincide with the Giants' biggest weakness of run defense.

Expect a lot of fireworks in this NFC East showdown that inevitably goes the Giants' way late.

Prediction: Giants 28, Eagles 24