Updated March Madness Odds for 2026 NCAA Men's Tournament Bracket Ahead of Sweet 16

With several teams punching their ticket to the Sweet 16 on Saturday, the latest March Madness odds have been revealed.

According to FanDuel Sportsbook, Duke is the favorite to win the men's NCAA tournament with +450 odds while Arizona holds the second-best odds at +400. Michigan sits at No. 3 with +310 odds, as Florida owns the fourth-best odds at +750.

Duke wrapped up an 81-58 win over TCU in the second round on Saturday, while Michigan defeated Saint Louis by the final score of 95-72.

The Blue Devils were led by Cameron Boozer, who continued his impressive freshman season with a double-double. Boozer finished with 19 points, 11 rebounds, four assists, three steals and one block while shooting 7-of-10 from the field against TCU.

Freshman guard Dame Sarr was also a factor for Duke, scoring 14 points and grabbing eight rebounds to go along with four three-pointers.

The national championship outlook for the Blue Devils may have been murky once they beat No. 16 seed Siena by a mere six points after trailing at halftime in the first round of the tournament, but they seemed to get back on track against the Horned Frogs.

Michigan got off to a slow start against Saint Louis on Saturday, trailing 27-23 with just over 10 minutes remaining in the first half.

The Wolverines quickly responded with a 7-0 run and led 48-39 at halftime, though. Michigan steadily extended its advantage to close out the second half of the contest, leading by as many as 25 points.

Yaxel Lendeborg put together an efficient performance for the Wolverines, scoring 25 points on 9-of-13 shooting. Michigan center Aday Mara also made an impact on both ends of the floor by racking up 16 points, five rebounds, five assists and four blocks.

Duke will face the winner of the clash between Kansas and St. John's in the Sweet 16, while Michigan is set to match up with the winner of Alabama and Texas Tech's second-round game.