Week 6 NFL Picks: Teams That Will Pull off Big Upsets

There are many big games to watch in Week 6, and a few teams are destined to pull off big upsets.

We saw some big upsets in Week 5, including the Indianapolis Colts taking down the Seattle Seahawks and the New York Jets beating the Atlanta Falcons on Monday Night Football. 

This week, we will see some upsets that are almost as big. Let's take a look at predictions for the full slate of games, followed by a breakdown of this week's biggest projected upsets.

Philadelphia Eagles (2-3) at Tampa Bay Buccaneers (0-4)

Date: Sunday, Oct. 13

Time: 1:00 p.m. ET

TV: Fox

Prediction: 27-24, Buccaneers

The Philadelphia Eagles have one of the most exciting offenses in the league, but it's not going to be enough to stop the Tampa Bay Buccaneers from getting their first win of the year.

Michael Vick suffered a hamstring injury last week against the New York Giants, and according to the NFL Network Twitter account, it looks like Nick Foles will likely be starting this Sunday.

Foles isn't a bad quarterback, and he should be able to run the offense as well as Vick can.  However, the Bucs defense is underrated this season.  They allow 332.3 total yards of offense per game, which is 13th in the league.  More importantly, they're allowing just 17.5 points per game, which ranks eighth in the NFL.

On the other hand, the Eagles defense is very bad.  They are the third-worst defense with regard to points allowed, giving up 31.8 points per game.  They also allow 434 total yards of offense a game, which is the second-worst mark in the league behind the Washington Redskins.

Mike Glennon likely isn't the long-term answer at quarterback for the Bucs, but he should be able to lead the offense to some points.  He still has Doug Martin in the backfield, and that defense should be able to frustrate the Eagles offense and make sure the game is close enough for Tampa Bay to finally come away with a win.

St. Louis Rams (2-3) at Houston Texans (2-3)

Date: Sunday, Oct. 13

Time: 1:00 p.m. ET

TV: Fox

Prediction: 17-14, Rams

The Houston Texans are struggling right now, and they appear to be lacking confidence.  That means this is a perfect opportunity for the St. Louis Rams to squeak out an upset win.

The Rams have had an up-and-down season so far, winning in Week 1 and losing three straight before the win last week over the Jacksonville Jaguars.

The ground game has been struggling to start the season, ranking 29th in the league and averaging just 66.4 yards per game.  However, Sam Bradford is carrying the team through the air with a pretty solid season so far.  He's thrown for 1,315 yards and 10 touchdowns with just three interceptions through the first five games.

Defensively, this team has shown flashes of greatness, but it has struggled with consistency.  Robert Quinn has led the front seven and is off to a great start this season with five sacks and four tackles for loss.  However, the secondary has been a huge liability with an uncharacteristically bad season from Cortland Finnegan.

Meanwhile, the Texans offense has been struggling as of late.  Houston has lost its last three games, putting up less than 11 points per game over that span.  Matt Schaub has broken an NFL record with four straight games with a pick-six.  During this losing streak, he's thrown just two touchdowns and six interceptions.

The defense is solid thanks to J.J. Watt, but defense can't win games by itself.  The Texans will struggle on offense to put up enough points, and the Rams will capitalize on some key turnovers to come away with a huge win.  

Washington Redskins (1-3) at Dallas Cowboys (2-3)

Date: Sunday, Oct. 13

Time: 8:30 p.m. ET

TV: NBC

Prediction: 30-24, Redskins

A bye week is just what the Washington Redskins needed entering this game, and that should help them pull out a win and get back into the divisional race.

Robert Griffin III has looked better each week.  He's continued to look more comfortable on the field, stepping into more throws and sliding in the pocket to avoid pressure.  He should be able to make some big throws through the air when he plays against a Cowboys defense that allows 326.4 passing yards per game.

Defense is where the Redskins are going to need to refocus.  They're allowing 440.5 yards and 28 points per game, which is not want you want entering a game against an offense with Tony Romo, Dez Bryant and DeMarco Murray.

The big advantage for the Redskins is that they will be well-rested coming into the game thanks to the bye week. Meanwhile, the Cowboys just played in a wild shootout against the Denver Broncos last week, with 99 total points scored in that game.

Expect RGIII to have his big breakout game this week against the Cowboys' struggling defense, and expect the Redskins to pull off the upset win.