NFL Week 1 Picks: Home Teams That Have No Chance of Winning

The start of the new NFL season means every fanbase starts out with optimism and hope, but the Buffalo Bills are one of a few home teams that have no chance of winning their opening game.

Week 1 is often tough to predict as teams change so much over the offseason, but there are certain matchups that will be upsets if the home team can find a way to win. 

The teams on this list have plenty of question marks on their rosters, and they are facing tough opponents. That's not a good combination.

Here is a full schedule of Week 1 followed by a list of home teams that have no chance of winning. 

Buffalo Bills (vs. New England Patriots)

The New England Patriots will look a little different on offense this season, but it won't make a difference in Week 1. 

One of the most impressive streaks in the NFL is what the Patriots have done: They have not lost an opener in 10 years. Yes, that loss was at Ralph Wilson Stadium against the Buffalo Bills, but this team has changed quite a bit since then, and Tom Brady is on a completely different level.

Wes Welker is no longer with the Patriots, but they replaced him with Danny Amendola. Rob Gronkowski is still rehabbing, so Zach Sudfeld, who impressed in the summer, should see some passes coming his way at tight end.

Buffalo has talent on both sides of the ball. Fred Jackson and C.J. Spiller are good running backs. Steve Johnson has had three straight years with at least 1,000 receiving yards, and rookie Robert Woods should be a big playmaker at wideout.

As Kevin Patra of NFL.com reported on Wednesday, the Bills will start rookie EJ Manuel at quarterback. Having a rookie play against the Patriots in his first game is not a promising sign.

Mario Williams leads the defense, so they have some pieces in place. The Bills just aren't ready to compete with the Patriots yet, especially considering Jairus Byrd and Stephon Gilmore will be absent from the secondary.

In 19 meetings since beating the Patriots in the 2003 opener, the Bills are 1-18 against their division rival. The Bills have traveled to New England to open a season twice in that span and lost by a combined three points.

Buffalo has played some close games against New England, but it hasn't been able to come out on top. Add in the Patriots' incredible streak and roster, and the Bills have no chance in this one.

Jacksonville Jaguars (vs. Kansas City Chiefs)

This might be the first time ever that a team that went 2-14 one year and started the next season on the road would be a lock to win the opener. Kansas City has talent on its roster, and Jacksonville looks like it is headed for another long year.

It may have also been a first that a team with only two wins sent six players to the Pro Bowl, but that's exactly what the Chiefs did last year. Running back Jamaal Charles, outside linebacker Tamba Hali, outside linebacker Justin Houston, linebacker Derrick Johnson, safety Eric Berry and punter Dustin Colquitt all went to Hawaii last season.

Kansas City hired Andy Reid as coach and traded for quarterback Alex Smith. After a rocky start in the NFL, Smith had turned his career around in San Francisco before a concussion cost him his job.

The Chiefs have plenty of talent on their roster to rebound nicely this season.

On the other side, the Jaguars are a mess. They had a quarterback competition in the offseason before Blaine Gabbert won the job. Their star running back is returning from a foot injury, and receiver Justin Blackmon is suspended for the first four games of the regular season.

The Jaguars ranked 30th in total defense, run defense and points allowed. Having a poor run defense against a guy who ran for more than 1,509 yards last season is going to be a problem.

Kansas City was a bad team last year, but it is a lock to win its opener in Jacksonville.

San Diego Chargers (vs. Houston Texans)

The Houston Texans have won playoff games in back-to-back seasons. Meanwhile, the San Diego Chargers are just trying figure out how to get back to the postseason.

Receiver Danario Alexander is out for the year for the Chargers. Malcom Floyd and Eddie Royal will need to step up at receiver this year, and Keenan Allen will be expected play a big role as a rookie. 

Philip Rivers is still a good quarterback, but he needs protection and help around him.

Running back Ryan Mathews is productive when he's on the field, but he's never played in more than 14 games in a season. Antonio Gates is still the tight end, but he hasn't played in 16 games in three years.

The Texans are set on both sides of the ball. NFL Defensive Player of the Year J.J. Watt and Johnathan Joseph are Pro Bowlers on defense.

Matt Schaub still gets the ball to Pro Bowl receiver Andre Johnson and tight end Owen Daniels. Running back Arian Foster is one of the best in the league. The Texans are extremely balanced on offense, so the Chargers will have a hard time stopping them.

San Diego's defense ranked in the top 10 last year, but the offense is going to need to find a way to move the ball and score points.

The Chargers offense ranked 20th in points and 31st in yards per game. Unfortunately for the Chargers, Houston's defense finished seventh in total defense and tied for ninth in points allowed. That doesn't bode well for them.

Although they went 7-9 last year, the Chargers finished 3-5 at home.

Houston is one of the best teams in the NFL, so San Diego has no chance in this game. 

*All stats are courtesy of NFL.com