Week 6 NFL Predictions: Latest Odds and Picks Against the Spread

The slate of games for Week 6 in the NFL is more fascinating than given credit.

Obviously Sunday's featured game between the Green Bay Packers and Houston Texans will be exciting. After all, it's Aaron Rodgers going against arguably the best defense pro football has to offer.

Elsewhere, though, other big games come from the New York Giants against the San Francisco 49ers and the New England Patriots facing the Seattle Seahawks.

A rematch of the 2011 NFC Championship, can Eli Manning and Co. steal another victory at Candlestick Park?

In the Great Northwest, will Tom Brady and the Pats fend off Seattle's impressive defense?

To that end, let's sink our teeth into Week 6 and check out what to do with the latest spreads.

Note: All spreads are courtesy of FootballLocks.com

Bengals-Browns, Raiders-Falcons, Rams-Dolphins

Bengals (-2.5) at Browns

The Cincinnati Bengals are only one of two road teams favored to win in Week 6.

Being that they're playing at Cleveland, this comes as no surprise. Still, although the Browns are winless, this team has faced a rugged schedule.

Because Cincy's defense has lacked against the pass and run compared to 2011, Trent Richardson can dominate throughout.

Take the Browns and the points

Raiders at Falcons (-9.5)

The Oakland Raiders' best odds here are to slam the rock on the ground with Darren McFadden. The Falcons are weaker against the run, and doing so would limit Atlanta's offensive possessions.

That said, anticipate the Dirty Birds to stack the box and force Oakland to throw. Falcons' pass rush and coverage defenders will cause turnovers and keep McFadden in check.

Take the Falcons against the spread

St. Louis at Miami (-4.5)

This game will be won within seven points. So the question obviously remains: who to take?

Well, each team has a sound pass defense but is more vulnerable against the run. On the offense, Ryan Tannehill's has a better receiving corps overall and Reggie Bush is gradually emerging as a difference-maker.

Take the Dolphins against the spread

Colts-Jets, Lions-Eagles, Chiefs-Buccaneers

Indianapolis at NY Jets (-3.5)

It's a desperate must-win game for Rex Ryan and the New York Jets.

Riding a three game losing streak, except the Jets to bring even more this week than last.

Well, the Colts will be ready because Andrew Luck and the offense are quite capable of putting points up consistently. Indy fields sound playmakers defensively and its not like New York's offense has been reliably explosive.

Take the Colts and the points

Detroit at Philadelphia (-3.5)

If Michael Vick doesn't turn the rock over, Philadelphia will totally crush Detroit. The Lions' defense remains inconsistent and the talent for the Eagles is capable of creating numerous big plays.

Philadelphia's defense is also stellar. With the ability to pass rush, stuff the run and blanket in man coverage, Detroit will have trouble moving the ball. Unless the Lions are able to present a balanced attack, this game can get out of hand early.

Take the Eagles against the spread

Kansas City at Tampa Bay (-4)

Kansas City at Tampa Bay will be quite low-scoring. The offenses feature solid running backs—Jamaal Charles (K.C.) and Doug Martin (Tampa)—as well as one standout receiver (Dwayne Bowe for the Chiefs and Vincent Jackson for the Bucs).

That however, makes it easier for a defense because it can play single coverage while stacking the box. In turn, whichever quarterback makes more consistent pre-snap reads will be key.

Take the Buccaneers against the spread

Cowboys-Ravens, Patriots-Seahawks, Bills-Cardinals

Dallas at Baltimore (-3)

The Cowboys vs. the Ravens is one intriguing matchup.

Rob Ryan's defense and DeMarcus Ware are going somewhat under the radar, because much attention is going to Tony Romo and the offense's lack of consistency.

As for Baltimore, the Ravens are uncharacteristically inconsistent at defending the run and pass.

Had it not been for Baltimore's balanced offense, the Ravens would be worse than 4-1. Turnovers will be key and each side has playmakers, however, none better than Ed Reed.

Take the Ravens against the spread

New England (-3.5) at Seattle

The other road favorite comes unsurprisingly from Tom Brady and the New England Patriots. Facing a dominant Seahawks' defense that plays well across the spectrum and gets impressive quarterback pressure, Brady has his hands full.

Fortunately for the Pats, Seattle's offense lacks explosion and Bill Belichick can stack the box to isolate Marshawn Lynch. Here, the more proven quarterback gets his team the win.

Take the Patriots against the spread

Buffalo at Arizona (-4)

With the Buffalo Bills still needing to find their pass rush, the Arizona Cardinals still need to find their pass protection.

Flip the switch and Arizona's defense can get quarterback pressure and Ryan Fitzpatrick is turnover-prone at times.

In short, the Card's have a more reliable pass rush and the presence of Larry Fitzgerald bails out Arizona's horrendous pass protection.

Take the Cardinals against the spread

Giants-49ers, Vikings-Redskins, Packers-Texans, Broncos-Chargers

NY Giants at San Francisco (-6.5)

A rematch of the NFC Championship will be one of the best games in Week 6.

San Francisco looks like the more talented team top to bottom, however, we've learned far too many times to never count out Eli Manning.

The Giants still provide excellent pass protection and Manning's ability to read pre-snap and make in-game adjustments are among the best around.

As for the 49ers, maintaining balance on offense and being physical on defense is expected. All that said, this will be a nail-biting finish.

Take the Giants and the points

Minnesota at Washington (-1)

The Vikings in Washington could certainly be Christian Ponder's breakout performance.

The Redskins are vulnerable against the pass and must put emphasis on shutting down Adrian Peterson. Provided Minnesota remains balanced, the Redskins won't control the game tempo.

Also, watch out for the Vikings' defense which is capable of totally limiting the Redskins' offense with a pass rush to force Mike Shanahan into being one-dimensional.

Take the Vikings and the points

Green Bay at Houston (-3.5)

It's gut-check time for the Green Bay Packers. On the road against the undefeated Houston Texans, Titletown faces a crucial must-win contest.

Not to mention, but Houston also fields one of the NFL's best all-around defenses. Additionally, the Packers pass protection and ground game has been inconsistent.

Considering that the Texans also present a balanced approach to Green Bay's defense, this game will gradually get out of hand.

Take the Texans against the spread

Denver at San Diego (Even)

It's not surprising to see the line even, because the Broncos and Chargers are eerily similar from an all-encompassed perspective.

Both teams have excellent quarterbacks, use multiple running backs, have an array of receiving targets, sound pass-rushers and playmakers against the pass. To that end, this game will strictly come down to the offensive line.

The Chargers are more skeptical in pass protection and with Manning being the better quarterback, Denver's ground game also produces more.

Broncos over Chargers

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