San Francisco 49ers 2018 schedule
Tickets
| Aug 10 | Cowboys | W | 24–21 |
| Aug 19 | @Texans | L | 16–13 |
| Aug 25 | @Colts | L | 23–17 |
| Aug 31 | Chargers | L | 23–21 |
| Sep 9 | @Vikings | L | 24–16 |
| Sep 16 | Lions | W | 30–27 |
| Sep 23 | @Chiefs | L | 38–27 |
| Sep 30 | @Chargers | L | 29–27 |
| Oct 7 | Cardinals | L | 28–18 |
| Oct 16 | @Packers | L | 33–30 |
| Oct 21 | Rams | L | 39–10 |
| Oct 28 | @Cardinals | L | 18–15 |
| Nov 2 | Raiders | W | 34–3 |
| Nov 13 | Giants | L | 27–23 |
| Nov 25 | @Bucs | L | 27–9 |
| Dec 2 | @Seahawks | L | 43–16 |
| Dec 9 | Broncos | W | 20–14 |
| Dec 16 | Seahawks | W | 26–23 |
| Dec 23 | Bears | L | 14–9 |
| Dec 30 | @Rams | L | 48–32 |