San Francisco 49ers vs. Arizona Cardinals - September 27, 2026

ARIou:48.5

Sep 27 @ 04:05pmon FOX

SF-8.5

Preview

Standings

Levi's StadiumSanta Clara, CA

Injuries

A. BillingsDL

Knee

QST

D. Taylor-DemersonS

Ribs

QST

I. AdamsOL

Knee

QST

I. SeumaloOL

Shoulder

QST

M. MeltonCB

Ankle

QST

R. LopezDL

Groin

QST

G. WilliamsCB

Achilles

OUT

Injuries

E. PineiroK

Illness

QST

K. BlackRB

Groin

QST

D. StriblingWR

Ankle

OUT

Live Odds	Spread	O/U	Moneyline
Arizona Cardinals	+8.5 -105	O 48.5 -110	+410
SF 49ers	-8.5 -115	U 48.5 -110	-550

Team Comparison

ARI

SF

1-0

SEASON RECORD

1-0

1-0

RECORD vs. SPREAD

1-0

1-0 (A)

HOME/AWAY

0-0 (H)

W1

TEAM STREAK

W1

League Rankings

ARI

SF

14th(26)

PTS/G

9th(27)

8th(14)

PTS/G ALLOWED

1st(7)

6th(393)

TOTAL YDS/G

9th(379)

5th(277)

PASS YDS/G

15th(205)

13th(116)

RUSH YDS/G

3rd(174)

7th(268)

YDS/G ALLOWED

12th(290)

5th(+2)

TO DIFF

10th(+1)

Season Leaders

ARI

SF

J. Brissett277 YDS

PASSING YARDS

B. Purdy205 YDS

J. Brissett1 TD

PASSING TDS

B. Purdy3 TD

T. Allgeier61 YDS

RUSHING YARDS

C. McCaffrey68 YDS

J. Love1 TD

RUSHING TDS

----

T. McBride95 YDS

RECEIVING YARDS

D. Robinson50 YDS

T. McBride1 TD

RECEIVING TDS

D. Samuel1 TD

A. Wingard1 INT

INTERCEPTIONS

R. Green1 INT

J. Gibbens5 TACKLE

TACKLES

F. Warner5 TACKLE

J. Burch1 SACK

SACKS

----

Spread

Will SF win by 9 or more points? Or, will ARI avoid losing by 9 or more points?

Arizona Cardinals

SF 49ers

+8.5

-105

-8.5

-115

41%

59%

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Total Points

How many points will both teams score, combined?

Arizona Cardinals

SF 49ers

O 48.5

-110

U 48.5

-110

O36%

U64%

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Moneyline

Who will win the game?

Arizona Cardinals

SF 49ers

+410

-550

1%

99%

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