NFL Week 10 Picks: Can the Patriots Upset the Steelers?

NFL Week 10 is upon us, and although it's Sunday morning, it's never too late for some last minute picks.

There are a lot of great matchups this week, but the main event looks to be the Steelers vs. the Patriots on Sunday night, when two of the top teams in the AFC collide for dominance.

There's a lot to go over, so let's get right to it.

For all the NFL and Patriots coverage you can handle, follow @e_frenz on Twitter by clicking the link here.

Detroit Lions at Buffalo Bills

Andrew Burton/Getty Images

EAST RUTHERFORD, NJ - OCTOBER 17: Shaun Hill #14 of the Detroit Lions drops back to pass against the New York Giants at New Meadowlands Stadium on October 17, 2010 in East Rutherford, New Jersey. (Photo by Andrew Burton/Getty Images)

Even without Matthew Stafford under center, the Lions still have a chance to win a road game after 24 consecutive road losses.

The Bills are still searching for their first win and won't be giving up on their home field, but with Jahvid Best taking the hand-offs, the Lions offense could prove to be just too much.

Winner: Detroit Lions

Minnesota Vikings at Chicago Bears

Jonathan Daniel/Getty Images

CHICAGO - DECEMBER 28: Brett Favre #4 of the Minnesota Vikings is sacked by Mark Anderson #97 of the Chicago Bears as Phil Loadholt #71 holds Anderson to the ground at Soldier Field on December 28, 2009 in Chicago, Illinois. The Bears defeated the Vikings

Brett Favre returns to one of his least favorite places in the world: Soldier Field. The Bears defense is one of the best in the league against both the run and the pass. The Vikings will still be without Sidney Rice, and they needed a career day from Favre to get past the dreadful Cardinals.

I don't expect it to be an easy day for Favre against the Bears, but the anemic Jay Cutler-led Bears offense doesn't look much more promising. Expect a defensive struggle.

Winner: Minnesota Vikings

New York Jets at Cleveland Browns

Matt Sullivan/Getty Images

CLEVELAND - NOVEMBER 07: Running back Peyton Hillis #40 and Alex Mack #55 of the Cleveland Browns celebrate after a touchdown against the New England Patriots at Cleveland Browns Stadium on November 7, 2010 in Cleveland, Ohio. (Photo by Matt Sullivan/Ge

The Browns defense has shown the ability to shut down some of the league's best offenses, and suffice it to say, the Jets offense is nowhere near that category.

Of course, the Browns haven't faced a defense that's quite as aggressive or as stifling against the run as the Jets defense, so they could find it harder to play the ball-control style of offense that they'd like to play.

Winner: Cleveland Browns

Cincinnati Bengals at Indianapolis Colts

Jim McIsaac/Getty Images

PHILADELPHIA - NOVEMBER 07: Peyton Manning #18 of the Indianapolis Colts in action against the Philadelphia Eagles on November 7, 2010 at Lincoln Financial Field in Philadelphia, Pennsylvania. (Photo by Jim McIsaac/Getty Images)

Despite all the prognostications of doom for the Colts after last week's narrow defeat at the hands of the Eagles, none of the Colts' three losses have come at home.

Peyton Manning has had a field day playing some defenses tougher than the Bengals', which ranks in the middle of the pack. Even without many of his favorite weapons, Manning can still work his magic, and I'd fully expect him to find the likes of Jacob Tamme and Pierre Garcon all day if he has to.

Winner: Indianapolis Colts

Houston Texans at Jacksonville Jaguars

Bob Levey/Getty Images

HOUSTON - NOVEMBER 07: Quarterback Matt Schaub #8 of the Houston Texans t takes the snap against the San Diego Chargers at Reliant Stadium on November 7, 2010 in Houston, Texas. (Photo by Bob Levey/Getty Images)

The Jaguars pass defense hasn't been able to stop virtually anyone from getting a ton of yards. They've already given up 2,137 yards, the 28th-most in the league.

Against Matt Schaub and Andre Johnson? Good luck with that, Jacksonville.

Winner: Houston Texans

Tennessee Titans at Miami Dolphins

Andy Lyons/Getty Images

NASHVILLE, TN - OCTOBER 24: Will Witherspoon #92 and Stephen Tulloch #55 of the Tennessee Titans celebrates in the fourth quarter during the NFL game against the Philadelphia Eagles at LP Field on October 24, 2010 in Nashville, Tennessee. The Titans won

The Titans' 5-3 record isn't the most impressive in the league, but they are playing at just as high a level as any of the elite teams.

The Dolphins couldn't have picked a worse game to substitute Chad Henne for Chad Pennington, whom has been sitting on the bench for a full season. The Titans defense has allowed just nine passing touchdowns while intercepting 13 passes and tallying 26 sacks.

Winner: Tennessee Titans

Carolina Panthers at Tampa Bay Buccaneers

Jamie Sabau/Getty Images

CINCINNATI, OH - OCTOBER 10: Head Coach Raheem Morris of the Tampa Bay Buccaneers watches his team play the Cincinnati Bengals at Paul Brown Stadium on October 10, 2010 in Cincinnati, Ohio. (Photo by Jamie Sabau/Getty Images)

Say what you want about the Buccaneers and head coach Raheem Morris, one thing they've done very well this season is beating the teams they're supposed to beat.

At 1-7, I'd say the Panthers fall into that category.

Winner: Tampa Bay Buccaneers

Kansas City Chiefs at Denver Broncos

Jamie Squire/Getty Images

KANSAS CITY, MO - SEPTEMBER 02: Defensive Coordinator Romeo Crennel of the Kansas City Chiefs looks on from the sidelines during the game against the Green Bay Packers on September 2, 2010 at Arrowhead Stadium in Kansas City, Missouri. (Photo by Jamie

The Chiefs have been the biggest surprise of the season but got handed a stinging loss by the second-biggest surprise, the Oakland Raiders.

This young team is playing like a veteran group, and a lot of that has to do with coaching. I'm sure Romeo Crennel, Charlie Weis and Todd Haley will have their guys ready to go against a weak Denver Broncos team.

Winner: Kansas City Chiefs

Seattle Seahawks at Arizona Cardinals

Harry How/Getty Images

GLENDALE, AZ - OCTOBER 31: Portrait of Larry Fitzgerald #11 of the Arizona Cardinals during warm up before the game against the Tampa Bay Buccaneers at University of Phoenix Stadium on October 31, 2010 in Glendale, Arizona. (Photo by Harry How/Getty Ima

After the two consecutive beatings the Seahawks have been handed by the Raiders and the Giants, they should be happy if anyone picks them this week—even against the Arizona Cardinals.

I don't expect the Cardinals to come out firing on all cylinders, but home field advantage has to be good for something, right?

Winner: Arizona Cardinals

Dallas Cowboys at New York Giants

Otto Greule Jr/Getty Images

SEATTLE - NOVEMBER 07: Running back D.J. Ware #28 of the New York Giants looks on during warmups prior to the game against the Seattle Seahawks at Qwest Field on November 7, 2010 in Seattle, Washington. The Giants defeated the Seahawks 41-7. (Photo by Ot

This is another one that seems almost unfair. The Cowboys have hardly been able to avoid beating themselves this season, much less look competitive against good teams. The Giants, needless to say, are up there as one of the best teams in the league right now.

The Giants handled the Cowboys in Dallas, and look ready to do even more damage to the Cowboys' painful season at New Meadowlands Stadium. Do we really expect Jason Garrett to get a win with this team in his first week as coach?

Winner: New York Giants

St. Louis Rams at San Francisco 49ers

Dilip Vishwanat/Getty Images

ST. LOUIS - OCTOBER 31: Sam Bradford #8 of the St. Louis Rams looks to pass against Eric Norwood #92 of the Carolina Panthers at the Edward Jones Dome on October 31, 2010 in St. Louis, Missouri. The Rams beat the Panthers 20-10. (Photo by Dilip Vishwana

Sam Bradford continues to make the Rams front office look like geniuses for drafting him at No. 1 this year. They couldn't ask for a better team to face coming off a win and a bye week than the San Francisco 49ers, who continue to reel from their slow start.

What's been even more impressive, though, is the Rams defense. They rank seventh in scoring so far and have given Bradford short fields and low scores to help him adjust to the game at his own pace.

Winner: St. Louis Rams

New England Patriots at Pittsburgh Steelers

Jim Rogash/Getty Images

FOXBORO, MA - OCTOBER 31: Tom Brady #12 of New England Patriots checks the clock with his coach Bill Belichick in the fourth quarter against the Minnesita Vikings at Gillette Stadium on October 31, 2010 in Foxboro, Massachusetts. (Photo by Jim Rogash/Get

This breakdown I wrote from earlier this week gives you all the insight you need into this game.

The Patriots rarely lose two games in a row and never look nearly as bad the next week after a poor performance.

Winner: New England Patriots

Monday Night Football: Philadelphia Eagles at Washington Redskins

Jim McIsaac/Getty Images

PHILADELPHIA - NOVEMBER 07: Michael Vick #7 of the Philadelphia Eagles throws a pass against the Indianapolis Colts on November 7, 2010 at Lincoln Financial Field in Philadelphia, Pennsylvania. The Eagles defeated the Colts 26-24. (Photo by Jim McIsaac/

Michael Vick. 'Nuff said.

I wasn't heavily convinced by the Redskins' early-season win over the Eagles, as it came with Vick playing only one half. The Eagles are the more talented team, and even though their quarterback carousel keeps moving, it's doing so in a much more organized manner than the one in Washington.

Winner: Philadelphia Eagles