The game will take place in Dyersville, Iowa, at a temporary ballpark built by MLB, located adjacent to the setting of the 1989 film Field of Dreams starring Kevin Costner.
It is scheduled to be the first MLB game to take place in the state of Iowa, with up to 8,000 fans potentially in attendance based on public health status.
The league had initially planned a game between the White Sox and Yankees at this location during the 2020 season, but the COVID-19 pandemic created adjustments to the regular-season schedule. The Cardinals later replaced the Yankees before it was postponed to next season.
Both the Yankees and White Sox have high expectations heading into 2021, each currently within the top six in odds to win the World Series on DraftKings.