"I'm not worried about a curse," Jackson said, referring to players who previously suffered injuries or dips in performance after appearing on the Madden cover.
The 23-year-old University of Louisville product is coming off a monster 2019 season, his second in the NFL. He completed 66.1 percent of his throws for 3,127 yards and a league-leading 36 touchdown passes against six interceptions. He added 1,206 yards and seven scores on the ground.
Along with the MVP Award, he earned his first All-Pro and Pro Bowl selections.
His success made him the obvious front-runner for the Madden cover.
Jackson will join a list of cover athletes that also features Marshall Faulk, Michael Vick, Ray Lewis, Tom Brady and, most recently, Patrick Mahomes.
Mahomes' success in leading the Kansas City Chiefs to the Super Bowl LIV championship after being on the cover last year led some to wonder if the Madden curse had been broken.
Jackson will look for his own Super Bowl title next season with the Ravens.