Cowboys vs. Eagles: Updated Odds, Money Line, Spread, Props to Watch for TNF

The 2025 NFL season will begin on Thursday night with a fantastic matchup between NFC East rivals.

The Philadelphia Eagles will begin their title defense against a Dallas Cowboys team that just shipped off its best player, Micah Parsons. Unsurprisingly, the Eagles are heavy favorites against their familiar foe.

While both of last year's games were blowout Eagles wins, things have been more even when Cowboys quarterback Dak Prescott has been healthy. These games have also featured quite a bit of scoring. If the latest edition follows suit, it should provide fans with some prime player-prop opportunities.

Let's take a look at the best wagering options for this year's opener.

Odds via DraftKings Sportsbook.

Updated Odds

AP Photo/Matt Slocum

Eagles QB Jalen Hurts and RB Saquon Barkley

Line: PHI -8.5 (61% of bets and 53% of money on Eagles, according to DraftKings)

Money Line: PHI -395, DAL +310 (88% of bets on Eagles, according to DraftKings)

Over/Under: 47.5

The Eagles won last year's two meetings by a combined score of 75-13. However, it should be noted that Prescott missed both games for Dallas, and the Cowboys had several other injuries.

Over the past five years, these teams have won five games apiece. The home team has gone 8-2 over that span.

While everything favors the Eagles in this matchup, the line is a tricky one. It would be a massive shock to see Philly actually lose, but a garbage-time Cowboys score could easily lead to a back-door cover. The Cowboys' strength is their passing game, and the Eagles have some question marks in the secondary.

The over/under feels like a safer play than the line, given the way these teams match up. Dallas should find aerial success against the Eagles, while Philadelphia should bowl over a suspect run defense.

Six of the last 10 meetings between these two teams have resulted in 48 or more points. Cowboys-Eagles games have averaged 52.7 total points over the last five years.

Eagles Props to Watch

AP Photo/Matt Slocum

Saquon Barkley

Saquon Barkley Over/Under 93.5 Rushing Yards

The Eagles rode Saquon Barkley all the way to a championship last season, and they're unlikely to alter their game plan in 2025. Expect the reigning Offensive Player of the Year to get plenty of carries on Thursday night.

Last season, Barkley topped 100 rushing yards in only one game against Dallas, but he averaged more than 4.5 yards per carry in both. While the Cowboys did bring back defensive tackle Kenny Clark in the Parsons trade, it's hard to believe that Dallas' Run D has suddenly become good.

The biggest threat to the over here might be an early and substantial Philly lead. The Eagles could look to close things out with Will Shipley and/or AJ Dillon in an effort to keep Barkley fresh for later in the year.

Saquon Barkley First-Half Anytime TD

While there's a chance that Barkley finishes the game as a spectator, the Eagles are likely to use him early and often against their divisional foes. In last year's second meeting with the Cowboys, he logged 31 carries and two receptions—he saw just 14 carries in the first meeting, a game that was closed out by Shipley and Kenneth Gainwell.

However, Barkley didn't find the end zone in either contest. In fact, he only scored touchdowns in eight of his 16 outings.

This makes a first-half anytime TD prop (145) riskier than it might initially feel. It's a much more enticing wager than a second-half anytime TD, though.

In last year's opener, Barkley found the end zone three times, twice in the opening half.

Cowboys Props to Watch

AP PhotoKirk Irwin

Dak Prescott

Dak Prescott Over/Under 248.5 Passing Yards

There are a few reasons to believe that Prescott will have a prolific game against the Eagles, even if it's in a loss. The biggest is that Dallas simply doesn't have a backfield on which it can lean.

Javonte Williams, Miles Sanders and Jaydon Blue form a trio that is likely to be serviceable at best.

The Eagles also have more question marks in their secondary than up front. They're searching for a reliable second perimeter corner, and they shipped off safety C.J. Gardner-Johnson in the offseason.

In two games against the Eagles in 2023, when Prescott was healthy, he threw for 645 combined yards. The over feels like the smart play here. However, there's no guarantee that Dallas will keep Prescott in the game if there's a blowout.

CeeDee Lamb Over 72.5 Receiving Yards

If the Eagles do pull ahead early, the Cowboys will try throwing their way back into the game. Regardless of how the early action unfolds, we can expect Prescott to target No. 1 receiver CeeDee Lamb early and often.

Dallas does have a couple of good complementary targets in George Pickens and Jake Ferguson. However, the passing attack still runs through Lamb. He was targeted an average of 10 times per game in 2024.

Again, the over feels like the safer play here. If Dallas keeps this one close, it'll likely be because of a strong performance by Lamb. If it doesn't, he'll have a chance to pile on garbage-time yardage.

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