NFL Picks Week 6: Teams Poised to Disappoint Home Crowds in Tough Matchups

Home field advantage is not all it is cracked up to be in the NFL.

Outside of Seattle and the dome in New Orleans, not many teams tout a game-changing advantage that makes them unstoppable in front of home fans.

While Week 6 is loaded with great games, several home teams will end up losing in front of their home crowd against superior opposition.

Here are three games sure to swing in the road team's favor this week.

Buffalo Bills Stumble Against Cincinnati

The Buffalo Bills need every advantage they can get against the Cincinnati Bengals with starting rookie quarterback EJ Manuel set to miss the game with a knee injury.

In Manuel's place will be Thad Lewis, an undrafted quarterback out of Duke in 2010. Lewis has one start in his career, which came for Cleveland last year in spot-duty.

While Lewis was not horrible in the outing as he went for 212 yards, a touchdown and an interception, he has a tough road ahead against a stout Cincinnati defense.

Cincinnati, led by a dominant defense line including tackle Geno Atkins and end Carlos Dunlap, ranks as the No. 8 overall unit.

The combo of Fred Jackson and C.J. Spiller, which allows the rushing attack to rank No. 3 overall, will be effectively bottled up by the Bengals' defensive front with no threat under center to worry about.

Prediction: Bengals 23, Bills 13

San Diego Won't Overcome Indianapolis

Monday Night Football in Week 6 boasts two teams heading in opposite directions. Andrew Luck and Indianapolis are building off a playoff appearance a year ago at 4-1 and first place in the AFC South.

Conversely, the Norv Turner nightmare is over for Philip Rivers in San Diego, but there is plenty of work to be done on a roster that has only managed a 2-3 record, good for third place in the AFC West.

Rivers (1,610 yards, 13 touchdowns) is experiencing a nice resurgence under Mike McCoy, but part of that is due to his No. 27 ranked defense that makes him consistently play from behind.

Indianapolis will have no issue dictating the pace of the contest on Monday night. The Colts allow just over 200 passing yards per game courtesy of a top-five unit in that regard, and also have one of the NFL's top-five rushing attacks.

While back Ahmad Bradshaw is officially out for the year per ProFootballTalk below, Trent Richardson is just beginning to hit his stride in his new home:

Expect the Colts to dominate this game in all phases, courtesy of a weak San Diego defense.

Prediction: Colts 27, Chargers 17

New England Unable to Match New Orleans Offense

While much of the talk surrounding the New England and New Orleans showdown concerns Patriots' tight end Rob Gronkowski, it sounds as if the elite tight end will be nothing more than a game-time decision at best per ESPN's Adam Schefter:

Regardless of Gronkowski's participation in the contest, he will be just the second-best tight end on the field.

The best resides in New Orleans, and his name is Jimmy Graham. As ESPN's Numbers Never Lie perfectly illustrates, Graham is the NFL's most unstoppable player given his current pace:

With Graham lining up in multiple positions and Drew Brees under center, the NFL's No. 2 passing attack (327 yards per game) will have no issue exploiting an average New England secondary that is simply middle-of-the-pack.

Furthermore, New Orleans now has a defense worth fearing, as the Saints tout the NFL's No. 11 ranked unit thanks to coordinator Rob Ryan. Expect Ryan and Co. to frustrate Tom Brady all day, especially if he is without Gronkowski.

Prediction: Saints 35, Patriots 20

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