NFL Week 1 Picks: Lines and Predictions for Every Opening Game

The 2013 NFL regular season is finally here, with some of the year's best matchups unfolding in Week 1 as all 32 teams set their sights on Super Bowl XLVIII. 

Even though it's just Week 1, we're set for some big-time matchups as playoff contenders clash all over the place, providing opportunity for plenty of betting lines and predictions.

Let's take a look at all of the upcoming Week 1 games and predictions, in addition to dissecting some of the biggest matchups of the opening weekend.

Note: All odds courtesy of Bovada

Steven Cook's Week 1 Predictions

Matchup	Time (ET)	TV	Location	Prediction
Baltimore at Denver	8:30 p.m.	NBC	Sports Authority Field at Mile High	Denver (W)
New England (-10.5) at Buffalo	1 p.m.	CBS	Ralph Wilson Stadium	New England
Cincinnati at Chicago (-3)	1 p.m.	CBS	Soldier Field	Cincinnati
Miami at Cleveland (-2)	1 p.m.	CBS	FirstEnergy Stadium	Miami
Atlanta at New Orleans (-3)	1 p.m.	Fox	Mercedes-Benz Superdome	New Orleans
Tampa Bay (-3) at NY Jets	1 p.m.	Fox	MetLife Stadium	Tampa Bay
Tennessee at Pittsburgh (-7)	1 p.m.	CBS	Heinz Field	Tennessee
Minnesota at Detroit (-4.5)	1 p.m.	Fox	Ford Field	Minnesota
NY Giants at Dallas (-3)	8:30 p.m.	NBC	Cowboys Stadium	NY Giants
Oakland at Indianapolis (-10.5)	1 p.m.	CBS	Lucas Oil Stadium	Indianapolis
Seattle (-3.5) at Carolina	1 p.m.	Fox	Bank of America Stadium	Seattle
Kansas City (-4) at Jacksonville	1 p.m.	CBS	EverBank Field	Kansas City
Green Bay at San Francisco (-4.5)	4:25 p.m.	Fox	Candlestick Park	San Francisco
Arizona at St. Louis (-4.5)	4:25 p.m.	Fox	Edward Jones Dome	St. Louis
Philadelphia at Washington (-3.5)	7 p.m.	ESPN	FedEx Field	Washington
Houston (-4.5) at San Diego	10:15 p.m.	ESPN	Qualcomm Stadium	Houston

Schedule information via ESPN 

Green Bay Packers at San Francisco 49ers

Arguably the two top teams in the NFC take center stage in a mid-afternoon clash at Candlestick Park.

It doesn't get much better than that. 

The Packers are out to get revenge on last year's playoff defeat at the hands of Colin Kaepernick and the deadly read-option, but they'll have to go into a hostile environment to do so. 

Aaron Rodgers doesn't typically let teams get the best of him two times in a row, and he's surrounded by plenty of receivers who can make plays. Whether it's Randall Cobb, James Jones or Jordy Nelson catching passes, Rodgers won't be at a shortage of options.

However, Green Bay is going up against one of the league's best defenses to start the season, and that's never a comforting dynamic.

If the 49ers can rely on their stingy defense and make opportunistic plays and Kaepernick has success with his running game setting up the pass, San Francisco should pull out the home win.

Atlanta Falcons at New Orleans Saints

The 'Niners and Packers catch much of the attention in the NFC Super Bowl conversation, but the Falcons and Saints are all too easily forgotten in that talk.

With Sean Payton back from his year-long suspension, New Orleans looks to erase a woeful 2012 season by revitalizing a turnover-prone offense and patching up one of the league's worst defenses.

Meanwhile, Atlanta folded in the playoffs yet again after being one of the NFC's top teams during the whole regular season. But with Matt Ryan happily financed for the long term and star receivers Roddy White and Julio Jones to go along with future Hall of Fame tight end Tony Gonzalez, this offense threatens to hang 40 on any opponent.

Payton has a bigger impact on Brees than goes noticed, from superior play-calling to the coach's ability to relate to his star player and keep him composed through adversity. 

Despite the Saints' woeful 2012 season, they were still able to beat Atlanta at home. That'll be the case again in 2013.