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Southern University Football 2022 Schedule
| Sat, Sep 3 | vsLions | 11:00PM UTC | W 0-86 | |
| Sat, Sep 10 | @LSU | 11:30PM UTC | L 17-65 | |
| Sat, Sep 17 | @Texas So. | 9:00PM UTC | L 0-24 | |
| BYE 😴 | ||||
| Sat, Oct 1 | vsUAPB | 11:00PM UTC | W 3-59 | |
| Sat, Oct 8 | @Prairie View | 9:00PM UTC | W 45-13 | |
| Sat, Oct 15 | vsAlcorn St. | 11:00PM UTC | W 17-21 | |
| Sat, Oct 22 | vsVLB | 9:00PM UTC | W 7-51 | |
| Sat, Oct 29 | @Jackson St. | 6:00PM UTC | L 0-35 | |
| Sat, Nov 5 | @Florida A&M | 10:00PM UTC | L 16-30 | |
| Sat, Nov 12 | vsMVSU | 8:00PM UTC | W 7-27 | |
| BYE 😴 | ||||
| Sat, Nov 26 | vsGrambling | 7:00PM UTC | W 17-34 | |
| Sat, Dec 3 | @Jackson St. | 9:00PM UTC | L 24-43 | |