Southern Miss Football 2018 schedule
Tickets
| Sep 1 | Jackson State | T | 0–0 |
| Sep 8 | Louisiana-Monroe | L | 21–20 |
| Sep 22 | Rice | W | 40–22 |
| Sep 29 | @Auburn | L | 24–13 |
| Oct 13 | @North Texas | L | 30–7 |
| Oct 20 | UTSA | W | 27–17 |
| Oct 27 | @Charlotte | L | 20–17 |
| Nov 3 | Marshall | W | 26–24 |
| Nov 11 | @UAB | L | 26–23 |
| Nov 17 | Louisiana Tech | W | 21–20 |
| Nov 24 | @UTEP | W | 39–7 |