Louisville Cardinals Football 2022 Schedule
| Sun, Sep 4 | @Syracuse | 12:00AM UTC | L 31-7 |
| Fri, Sep 9 | @UCF | 11:30PM UTC | W 20-14 |
| Fri, Sep 16 | vsFlorida St. | 11:30PM UTC | L 35-31 |
| Sat, Sep 24 | vsUSF | 4:00PM UTC | W 41-3 |
| Sat, Oct 1 | @BC | 4:00PM UTC | L 34-33 |
| Sat, Oct 8 | @UVa | 4:00PM UTC | W 34-17 |
| BYE 😴 |
| Sun, Oct 23 | vsPitt | 12:00AM UTC | W 24-10 |
| Sat, Oct 29 | vsWake Forest | 7:30PM UTC | W 48-21 |
| Sat, Nov 5 | vsJMU | 11:30PM UTC | W 34-10 |
| Sat, Nov 12 | @Clemson | 8:30PM UTC | L 31-16 |
| Sat, Nov 19 | vsNC State | 8:30PM UTC | W 25-10 |
| Sat, Nov 26 | @Kentucky | 8:00PM UTC | L 26-13 |
| Sat, Dec 17 | vsCincinnati | 4:00PM UTC | W 24-7 |
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