NFL Week 4 Live Fantasy Football Start 'Em Sit 'Em Lineup Advice and Latest Injury Updates

Fantasy managers hoping for a big game from Commanders wide receiver Stefon Diggs Sunday morning with Terry McLaurin out may have wished they had slept in.

I'm not sure Athan Kaliakmanis is a real person.

Baltimore Ravens wide receiver Zay Flowers racked up six catches for 84 yards in Brazil last week--an impressive stat line given that he played just 21 snaps.

Flowers' fantasy managers will be glad to hear that Sunday against the Titans he should be on the field a lot more--he's expected to play without limitations in Week 4.

Carolina Panthers wide receiver Jalen Coker got off to a torrid start over the first two weeks of the 2026 season.

But Coker left last week's loss to the Cleveland Browns with a quad injury, and that injury is expected to sideline him Sunday night against the Lions.

Don't wait to replace him in fantasy lineups--there isn't much in the way of backup plans playing in that contest.

For fantasy managers who spent their first-round pick on Los Angeles Rams wide receiver Puka Nacua, hearing that the fourth-year pro would return Sunday against the Philadelphia Eagles is good news.

Hearing that he won't be limited is even better.

Of course, for Davante Adams managers the news is a little less welcome--but them's the breaks.

Given the sorry state of the Tennessee offense, starting any Titans player in fantasy doesn't inspire a lot of confidence.

But many fantasy managers are fresh out of options in the backfield, and Tyjae Spears is expected to play Sunday against the Baltimore Ravens despite an ankle injury.

The good news is that Los Angeles wide receiver Ladd McConkey is expected to play through his foot injury Sunday against the Seattle Seahawks.

The bad news is that he'll be playing for the floundering Chargers.

With wide receiver DeVonta Smith expected to miss multiple games with a hamstring injury, it will fall to Dontayvion Wicks and rookie Makai Lemon to serve as the Eagles' top two wide receivers Sunday against the Los Angeles Rams.

However, the Rams are a below-average fantasy matchup for both wide receivers and quarterbacks, so whether it's those young pass-catchers or Eagles quarterback Jalen Hurts, Week 4 could be a tricky one.

This isn't to say you should sit Hurts. But if you have a Plan B with a solid matchup it's not the worst idea ever.

Emmanuel Wilson was already a hot name on waiver wires after Seattle running back Jadarian Price was ruled out for Week 4 with a chest injury. Now that Price is on injured reserve though, the Seattle backfield is looking--less than ideal.

Zach Charbonnet has been designated for return, although whether that's Week 5 or Week 6 remains to be seen. Until then, it will fall to Wilson and George Holani to hold down the fort in the Seahawks backfield.

Jaxon Smith-Njigba should see approximately all the targets ever Sunday against the Los Angeles Chargers

Nothing like having a star player inactive in a 9:30 AM start in London to start the week off right.

This should be fun.