FC Spartak Moscow 2018 schedule
| Sep 20 | @Rapid Vienna | L | 2–0 |
| Oct 4 | Villarreal | T | 3–3 |
| Oct 25 | @Rangers | T | 0–0 |
| Nov 8 | Rangers | W | 4–3 |
| Nov 29 | Rapid Vienna | L | 2–1 |
| Dec 13 | @Villarreal | L | 2–0 |
| Sep 20 | @Rapid Vienna | L | 2–0 |
| Oct 4 | Villarreal | T | 3–3 |
| Oct 25 | @Rangers | T | 0–0 |
| Nov 8 | Rangers | W | 4–3 |
| Nov 29 | Rapid Vienna | L | 2–1 |
| Dec 13 | @Villarreal | L | 2–0 |