Cerro Porteno 2018 Schedule
| Feb 27 | @Monagas SC | W | 2–0 |
| Mar 14 | Defensor | W | 2–1 |
| Apr 18 | Grêmio | T | 0–0 |
| May 1 | @Grêmio | L | 5–0 |
| May 15 | @Defensor | W | 1–0 |
| May 23 | Monagas SC | W | 3–2 |
| Aug 10 | Palmeiras | L | 2–0 |
| Aug 31 | @Palmeiras | W | 1–0 |
| Mar 6 | @Mineiro | T | 0–0 |
| Mar 13 | Zamora FC | T | 0–0 |
| Apr 2 | Nacional | W | 1–0 |
| Apr 10 | Mineiro | W | 4–1 |
| Apr 25 | @Zamora FC | L | 2–1 |
| May 7 | @Nacional | T | 1–1 |
| Jul 24 | @San Lorenzo | T | 0–0 |
| Jul 31 | San Lorenzo | W | 2–1 |
| Aug 22 | @River Plate | L | 2–0 |
| Aug 29 | River Plate | T | 1–1 |