NFL Week 10: What Are the Top Storylines on Game Day?

Week 10 of the 2010 NFL regular season is set to begin, and as has been the case often this season, there are a ton of story lines to look at in games today.

Whether it is twin brothers facing each other on opposite sides of the field or a receiver who is now on his third team this season, the NFL is always full of surprises.

Without delay, here are 10 of the top story lines in no particular order.

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Rob Ryan vs. Rex Ryan: Twins Collide in Cleveland

The Cleveland Browns host the New York Jets on the coast of Lake Erie, and one of the many storylines in Cleveland are the Ryan brothers.

Rex dressed up like his brother earlier in the week and talked smack about Rob's weight.

Then on Friday Rob fired back at Rex and busted out a belt to reduce the size of his belly that Rex made fun off.

These two are a riot; ESPN even showed the brothers on the field at Cleveland Browns Stadium fake punching each other in the face.

Too funny.

Randy Moss's Debut As a Titan

Jeff Gross/Getty Images

MINNEAPOLIS - OCTOBER 17: Wide receiver Randy Moss #84 the Minnesota Vikings looks on prior to the start of the game against the Dallas Cowboys at Mall of America Field on October 17, 2010 in Minneapolis, Minnesota. (Photo by Jeff Gross/Getty Images)

Randy Moss is on team No. 3 this season after starting with the New England Patriots, then getting traded to the Minnesota Vikings, only to be cut.

Now the Tennessee Titans look to utilize his talent to get into the playoffs this season.

Head coach Jeff Fisher is the longest tenured coach in the league, and if anyone can control Moss, hopefully it will be Fisher.

But Fisher might be in for a surprise with one of the NFL's most emotional and attitude-fueled players.

Lions vs. Bills: Can Buffalo Get Win No. 1 Against Detroit?

Rick Stewart/Getty Images

TORONTO, ON - NOVEMBER 07: Steve Johnson #13, David Martin #80, and CJ Spiller #21 of the Buffalo Bills take the field prior to playing the Chicago Bears at Rogers Centre on November 7, 2010 in Toronto, Canada. (Photo by Rick Stewart/Getty Images)

The Bills host the Lions in a Great Lakes battle.

Having been competitive in their last three games, only losing each one by three points, the Bills are ready for a possible upset in Week 10—and the Lions may be on the receiving end.

Can the Bills win their first?

Fans will have to wait and see.

Can Troy Smith Save Both The 49ers' Season and Mike Singletary's Job?

Warren Little/Getty Images

LONDON, ENGLAND - OCTOBER 31: Troy Smith #1 of San Francisco 49ers in action during the NFL International Series match between Denver Broncos and San Francisco 49ers at Wembley Stadium on October 31, 2010 in London, England. This is the fourth occasion w

San Francisco 49ers head coach Mike Singletary has been on the hot seat for much of this season, but after a win in London, that seat has cooled a bit.

New starting quarterback Troy Smith is starting his second straight game, and after a solid first start, he could help lead this team to a turnaround this season—in a struggling division, an 8-8 record could win it.

Can Smith be the Bay Area's new leader and turn this team around?

Both the fans and Singletary hope so.

Braylon Edwards Goes Back To Cleveland

Al Bello/Getty Images

EAST RUTHERFORD, NJ - SEPTEMBER 19: Braylon Edwards #17 of the New York Jets looks on during warmups prior to the game against the New England Patriots on September 19, 2010 at the New Meadowlands Stadium in East Rutherford, New Jersey. (Photo by Al Be

New York Jets receiver Braylon Edwards goes back to the city where his career started for the first time since he was traded at the beginning of the 2009 season.

Sans the beard, Edwards looks to back up his consistent, non-stop trashing talk of the city of Cleveland with a solid game.

But if he drops passes, look for Browns fans in Cleveland Browns Stadium to cheer louder than they have all season long.

There is definitely some bad blood here, and if Edwards struggles, he is sure to get harassed by a rowdy Dawg Pound.

Can Big D Beat Big Blue In an NFC East Showdown

Otto Greule Jr/Getty Images

SEATTLE - NOVEMBER 07: Quarterback Eli Manning #10 of the New York Giants points at the line of scrimmage against the Seattle Seahawks at Qwest Field on November 7, 2010 in Seattle, Washington. The Giants defeated the Seahawks 41-7. (Photo by Otto Greule

The Dallas Cowboys have a new interim head coach Jason Garrett after Wade Phillips was fired, and right off the bat Garrett has to face the New York Giants in an NFC East road game classic.

Can Garrett get the Cowboys to maximize their talent in all facets of the game?

It will be a tough task in New York against one of the hottest teams in the NFL.

Monday Night Football: Can Michael Vick Get His Revenge?

Jim McIsaac/Getty Images

PHILADELPHIA - NOVEMBER 07: Michael Vick #7 of the Philadelphia Eagles runs the ball against the Indianapolis Colts on November 7, 2010 at Lincoln Financial Field in Philadelphia, Pennsylvania. The Eagles defeated the Colts 26-24. (Photo by Jim McIsaac/

Michael Vick sustained his rib injury against the Redskins, and now that he is 100 percent healthy he looks to get some revenge.

Or will Donovan McNabb step up his game and beat his former team?

Or will McNabb even start?

Too many story lines in this one—it should be an entertaining game.

Any Others?

Jim McIsaac/Getty Images

PHILADELPHIA - NOVEMBER 07: Peyton Manning #18 of the Indianapolis Colts in action against the Philadelphia Eagles on November 7, 2010 at Lincoln Financial Field in Philadelphia, Pennsylvania. (Photo by Jim McIsaac/Getty Images)

With so many more storylines, what others do you think are important?

How about the fact that Indianapolis Colts quarterback Peyton Manning keeps losing his weapons on offense to the Injured Reserve?

Please feel free to list them in the comments below.