In an appearance on ESPN's The Jump, Friedell (h/t Jack Maloney of CBS Sports) said, "The young players on the Bulls really can't stand Dwyane. It's no secret in Chicago, they have had enough."
Earlier in the offseason, Wade opted in to the final year of his contract with the Bulls and is set to collect nearly $24 million.
Friedell added that it's "inevitable" that the Bulls and Wade are set to part ways, and that it is "just a matter of when, not if."
After spending the first 13 years of his career with the Miami Heat, Wade signed with his hometown Bulls last offseason.
Injuries were once again an issue for Wade, as he missed 22 contests. He was fairly productive when he played, however, averaging 18.3 points, 4.5 rebounds and 3.8 assists per game.
Wade was critical of his teammates at times last season, especially after a January loss to the Atlanta Hawks, per AFP (h/t Yahoo Sports): "I don't know if I see enough guys who really want it. Losses like this, it has to hurt them. I'm 35 years old, man. I got three championships. It shouldn't hurt me more than it hurts these young guys. They have to want it."
The Bulls made the playoffs as the No. 8 seed, but they were eliminated in the first round by the top-seeded Boston Celtics.
Chicago took steps toward a rebuild during the offseason by trading Jimmy Butler to the Minnesota Timberwolves for Zach LaVine, Kris Dunn and a first-round pick that was used to select Lauri Markkanen.
Wade is a 12-time All-Star and three-time NBA champion who could conceivably be a good mentor to the younger players, but Friedell's report suggests he hasn't garnered respect in the locker room.