Per Sam Kasan of Pens Inside Scoop, Crosby will play after clearing the concussion protocol.
Kasan's report also noted the Penguins are getting Conor Sheary back after he missed Game 4 with a concussion, as well.
Crosby has had concussion issues that have lingered throughout his career. He missed the first six games of the 2016-17 regular season due to the injury.
In the first three games of the series against Washington, Crosby had totaled four points, including two goals in Game 1.