NFL Week 12 Picks: Game Odds, Props, Lines and Over-Under Predictions

Beginning with a trio of Thanksgiving Day bouts and ending with a weekend full of playoff-shaping matchups, Week 12 of the NFL season is flooded with must-see affairs.

The three Thanksgiving contests may only feature two teams with winning records, but a lot is on the line in every single matchup between clubs still very much in the mix for playoff spots. Elsewhere, must-see divisional clashes and matchups between conference elite flood the slate.

Let's take a look into odds and predictions for each Week 12 battle.

Week 12 NFL Odds and Predictions

Away	Home	Spread	O/U	Prediction
Philadelphia Eagles	Detroit Lions	DET -2	45	20-17 DET
Carolina Panthers	Dallas Cowboys	DAL -1.5	45.5	27-20 CAR
Chicago Bears	Green Bay Packers	GB -9	46	35-21 GB
Minnesota Vikings	Atlanta Falcons	Even	46	24-17 MIN
St. Louis Rams	Cincinnati Bengals	CIN -10	42	27-17 CIN
New Orleans Saints	Houston Texans	HOU -3	47.5	30-24 NO
Tampa Bay Buccaneers	Indianapolis Colts	IND -3	46	20-17 IND
San Diego Chargers	Jacksonville Jaguars	JAX -4	46.5	27-24 JAX
Buffalo Bills	Kansas City Chiefs	KC -7	41.5	20-14 KC
Miami Dolphins	New York Jets	NYJ -3	42.5	23-21 NYJ
Oakland Raiders	Tennessee Titans	Even	44	24-17 TEN
New York Giants	Washington Redskins	NYG -2.5	46.5	30-24 NYG
Arizona Cardinals	San Francisco 49ers	ARI -11.5	45	30-13 ARI
Pittsburgh Steelers	Seattle Seahawks	SEA -3.5	45.5	24-20 SEA
New England Patriots	Denver Broncos	NE -3	44	24-20 NE
Baltimore Ravens	Cleveland Browns	CLE -2.5	41	17-14 CLE

Odds courtesy of Odds Shark.

Featured Matchup

New England Patriots at Denver Broncos

The two most recent kings of the AFC are facing off on a Sunday Night Football clash. Another chance to see the two best active quarterbacks of our time battle, right?

Well, not quite.

Tom Brady and the New England Patriots are still firing on all cylinders and take a 10-0 record into Sunday, but the same can't be said of Peyton Manning and the Denver Broncos—who sit at 8-2, but more importantly are without their leader.

After Brock Osweiler made his starting debut last week in a win against Chicago, he'll get the nod again against the Pats as Manning is still battling his foot injury, per NFL Network's Ian Rapoport:

The sad truth is the Broncos might be better off—at least in the short term—with Osweiler than with an obviously hobbled Manning. The Sheriff has been far from his usual dominant self in 2015, throwing a whopping 17 interceptions to just nine touchdowns. 

Meanwhile, Brady has thrown 25 touchdown tosses to just four interceptions, leading the Pats as they hope to finish 16-0 for the second time in his career.

The odds are with them to do it, as NFL on ESPN noted:

New England is still unbeaten, but looked far from unstoppable in its latest outing—an ugly 20-13 win over Buffalo. With its skill-position players dropping like flies, defenses are keying on Rob Gronkowski—who caught just two of his seven targets Monday against the Bills.

With the Denver defense proving incredibly stout this season, the Patriots will have a tough time again moving the ball down the field and dealing with pressure in the backfield. But it's just hard to see Osweiler dealing it around enough to thwart a similarly strong Pats defense.

Expect Brady to get it done and push the Pats to 11-0 in a tight affair.

Prediction: Patriots 24, Broncos 20