NFL Picks Week 10: Game-by-Game Advice for Current Vegas Spreads

The Week 10 game between the undefeated New England Patriots and the NFC East-leading New York Giants sets up as a rout.

The Patriots have a slew of offensive weapons, led by future Hall of Fame quarterback Tom Brady and nearly unstoppable tight end Rob Gronkowski, and the Giants have one of the worst pass defenses in the league.

The Giants gave up seven touchdowns to New Orleans quarterback Drew Brees in Week 8, and if Brees and his crew of mediocre wideouts could do that to New York, what can the Patriots do?

That's what the oddsmakers are thinking, as they have established the Patriots as eight-point favorites at MetLife Stadium, according to Odds Shark.

However, the Patriots have a serious injury issue, as versatile running back Dion Lewis suffered a torn ACL in the Pats' Week 9 victory over the Redskins, and he will miss the rest of the season.

The Pats have Julian Edelman, Danny Amendola, Brandon LaFell and pounding running back LeGarrette Blount, but the loss of Lewis will hurt.

Beating the Giants on their home turf may look predictable for the unbeaten Patriots, but New York quarterback Eli Manning is enjoying an excellent year with 19 touchdowns and just six interceptions.

While the Patriots have been playing well on the defensive side of the ball, they may have a very difficult time covering Odell Beckham Jr. He is as gifted as any receiver in the league, and New England will have a hard time matching up with him.

Additionally, Rueben Randle has become a very dangerous No. 2 receiver.

The Giants may not win this game, but they will keep the margin at less than eight points, and they will get the cover.

Game	Line	Over/Under	Selection
Buffalo at New York Jets	N.Y. Jets -2.5	42.5	Buffalo; Over
Jacksonville at Baltimore	Baltimore -5.5	48	Jacksonville: Over
Detroit at Green Bay	Green Bay -13	47.5	Detroit; Under
Miami at Philadelphia	Philadelphia -7	46.5	Philadelphia; Under
Cleveland at Pittsburgh	Pittsburgh -4.5	41	Pittsburgh; Over
Chicago at St. Louis	No line	--	St. Louis
Dallas at Tampa Bay	Tampa Bay -1	43	Tampa Bay; Under
Carolina at Tennessee	Carolina -4.5	43.5	Tennessee; Under
New Orleans at Washington	Even	50.5	Washington; Under
Minnesota at Oakland	No line	--	Oakland
Kansas City at Denver	Denver -7	41.5	Kansas City; Under
New England at New York Giants	New England -8	55	N.Y. Giants; Under
Arizona at Seattle	Seattle -3	45	Seattle; Under
Houston at Cincinnati	Cincinnati -12	47	Cincinnati; Over

Defenses will dominate as undefeated Panthers take on Titans

The Carolina Panthers have reeled off 12 straight regular-season wins since starting the 2014 season with a 3-8-1 record.

Quarterback Cam Newton is not rolling up a lot of yards (216.6 per game), but he is using his athleticism and making enough big plays, and that has allowed the Panthers to win every week.

The Titans came through with an upset win on the road against the Saints in Week 9, as rookie quarterback Marcus Mariota threw a game-winning touchdown pass in overtime.

While the Panthers and the Titans appear to have little in common, neither teams boasts a stable of high-level wide receivers. Ted Ginn Jr. has some speed for the Panthers, but he is not consistent in his route running. Tennessee wideout Kendall Wright has size and explosive speed, but he is not a finished product.

Both teams can run the ball and have high-level tight ends, but these are not explosive offensive teams. The Panthers rank 27th in passing yards gained, while the Titans rank 28th in total yards gained.

This appears to be a field position game and perhaps a battle of field goals. The linemakers have set the total at 43.5, but this appears to be a game where both teams will end up in the teens.

Take the under and don't look back.

Ronald Martinez/Getty Images

Low-priced Seahawks should be ready to surge in the second half

The Seattle Seahawks were unable to get it together in the first half of the season.

The two-time defending NFC champions struggled through their first eight games, and they are just 4-4 as they start the second half of the season.

The Seahawks beat the Cowboys in Week 8 before their bye week, and they start off with a key game at home against the NFC West-leading Arizona Cardinals.

Arizona has a formidable team with Carson Palmer at quarterback and a crew of receivers led by veteran Larry Fitzgerald, but when the Seahawks are playing to their potential on defense, they are tough to penetrate.

Look for defensive end Michael Bennett to put the pressure on Palmer throughout, and the rest of the Legion of Boom should also be ready to play.

The Seahawks are just three-point favorites, and that's basically an insult to a team that has been dominant at home.

This will be a close game, but Russell Wilson and Marshawn Lynch will punish the Cardinals in the fourth quarter, and the Seahawks will win by more than a touchdown.