Justin Jefferson, Puka Nacua, NFL Injury Statuses and Fantasy Impact for Week 4

The Minnesota Vikings have one of the best fantasy football matchups on paper in Week 4.

However, the Vikings will have to try to beat the Miami Dolphins without their biggest fantasy football star. Justin Jefferson was ruled out with the sprained ankle he suffered last week.

The news is much better for the Los Angeles Rams, who are expected to get Puka Nacua back after a two-week absence.

Nacua's matchup against the Philadelphia Eagles appears to be tough, but he's still expected to put up decent fantasy numbers on Sunday.

Below is a look at all of the significant injuries affecting fantasy football matchups in Week 4.

9:30 a.m. ET London Game

Keenan Allen	Questionable
Jayden Daniels	Out
Rachaad White	Out
Terry McLaurin	Questionable

1 p.m. ET Games

Drake Maye	Full Participant In Friday Practice
Keon Coleman	Questionable
D.J. Moore	Limited Participant in Friday Practice
Caleb Williams	Out
D’Andre Swift	Full Participant In Friday Practice
Breece Hall	Out
Adonai MItchell	Out
Jakobi Meyers	Limited Participant In Practice
Davante Adams	Full Participant In Practice
Puka Nacua	Will Play Sunday
Terrance Ferguson	Out
DeVonta Smith	Out
Dallas Goedert	Out
Baker Mayfield	Out
Chris Godwin	Will Play Sunday
Bucky Irving	Will Play Sunday
Tony Pollard	Will Play Sunday
Tyjae Spears	Questionable
Lamar Jackson	Will Play Sunday
Zay Flowers	Questionable
Nico Collins	Will Play Sunday

4 p.m. ET Games

Caleb Douglas	Did Not Practice
Justin Jefferson	Out
Rashee Rice	Full Participant In Practice
Patrick Mahomes	Full Participant In Practice
Ashton Jeanty	Full Participant In Practice
JK Dobbins	Full Participant In Practice
Jaylen Waddle	Full Participant In Practice
Christian McCaffrey	Full Participant In Practice
Mike Evans	Game-Time Decision
Ladd McConkey	Questionable
Zach Charbonnet	Limited Participant in Thursday Practice
Jadarian Price	Out

Sunday Night

Jalen Coker	Questionable
Bryce Young	Full Participant In Friday Practice
Chuba Hubbard	Full Participant In Friday Practice

Justin Jefferson Ruled Out

Justin Jefferson was ruled out for Minnesota's Week 4 contest with Miami.

Jefferson's status is a blow to fantasy football players who hoped he would take advantage of the matchup.

Miami's allowed seven passing touchdowns through three weeks, which is tied for the fifth-most in the NFL. The San Francisco 49ers and Kansas City Chiefs put up over 240 passing yards in the last two weeks versus the Miami defense.

Jordan Addison is the most obvious player to receive a production bump in Jefferson's absence. He's worth a waiver-wire look if he's still available in your league.

If not, Jauan Jennings is worth an addition because of his expected increase in production from the WR2 spot. Jennings hasn't done anything of note yet this season, but if there was any week to trust him in a FLEX or WR2 spot in fantasy, it would be Week 4.

There could be waiver-wire value elsewhere, especially for the Indianapolis Colts-Washington Commanders game in London. Both teams rank in the top five in passing yards allowed.

Washington's Stefon Diggs and Antonio Williams, as well as Indianapolis' Darius Slayton are worth riskier additions if you believe both defenses will continue to struggle against the pass.

Puka Nacua Expected to Return

Puka Nacua is off the injury report for the Rams' Week 4 trip to Philadelphia.

Nacua is going up against a Philadelphia defense that unexpectedly struggled on Monday night against Case Keenum and the Chicago Bears. The Eagles let up 247 passing yards and 27 points in the loss.

Nacua had some standout games against the Eagles in his career. He put up over 100 receiving yards in his last two regular-season meetings against the NFC East side. He also had 97 yards against the Eagles in the postseason.

The Rams star is always a must-start in fantasy football when healthy, but this could be an opportunity for him to put up big numbers in his return.

Davante Adams still exists within the Rams offense, but the two wide outs typically co-exist well alongside Matthew Stafford.

The rest of the Rams pass-catchers, who had value in Weeks 2 and 3 with Nacua out, carry diminished fantasy value with the star wide out back in the fold.