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Week 10 Fantasy Football Cheat Sheet for Sleepers in Deep Leagues

Kristopher KnoxNov 5, 2025

Week 10 could end up being an odd one in fantasy football. It's the first slate after the NFL's trade deadline, which means a few new faces in new places. Injuries remain an ongoing issue, and four teams are on bye again this week.

The Cincinnati Bengals, Dallas Cowboys, Kansas City Chiefs and Tennessee Titans will be out of action.

Managers looking for fill-ins and replacements will have options, though. Before we dive into this week's top waiver-wire targets, let's examine some updated point-per-reception (PPR) rankings.

Flex Top 40, Week 10

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49ers Giants Football
49ers RB Christian McCaffrey

1. Christian McCaffrey, RB, San Francisco 49ers

2. Puka Nacua, WR, Los Angeles Rams

3. Jonathan Taylor, RB, Indianapolis Colts

4. Jaxson Smith-Njigba, WR, Seattle Seahawks

5. De'Von Achane, RB, Miami Dolphins

6. Amon-Ra St. Brown, WR, Detroit Lions

7. Bijan Robinson, RB, Atlanta Falcons

8. James Cook, RB, Buffalo Bills

9. Jahmyr Gibbs, RB, Detroit Lions

10. Rico Dowdle, RB, Carolina Panthers

11. Justin Jefferson, WR, Minnesota Vikings

12. Davante Adams, WR, Los Angeles Rams

13. Saquon Barkley, RB, Philadelphia Eagles

14. Josh Jacobs, RB, Green Bay Packers

15. Drake London, WR, Atlanta Falcons

16. Emeka Egbuka, WR, Tampa Bay Buccaneers

17. Trey McBride, TE, Arizona Cardinals

18. Rome Odunze, WR, Chicago Bears

19. Kyren Williams, RB, Los Angeles Rams

20. Brock Bowers, TE, Las Vegas Raiders

21. Ladd McConkey, WR, Los Angeles Chargers

22. Oronde Gadsden II, TE, Los Angeles Chargers

23. Nico Collins, WR, Houston Texans

24. Jaylen Warren, RB, Pittsburgh Steelers

25. Jaylen Waddle, WR, Miami Dolphins

26. Derrick Henry, RB, Baltimore Ravens

27. Courtland Sutton, WR, Denver Broncos

28. Michael Pittman Jr., WR, Indianapolis Colts

29. J.K. Dobbins, RB, Denver Broncos

30. Zay Flowers, WR, Baltimore Ravens

31. Quinshon Judkins, RB, Cleveland Browns

32. A.J. Brown, WR, Philadelphia Eagles

33. Breece Hall, RB, New England Patriots

34. Marvin Harrison Jr., WR, Arizona Cardinals

35. Ashton Jeanty, RB, Las Vegas Raiders

36. D.J. Moore, WR, Chicago Bears

37. Wan'Dale Robinson, WR, New York Giants

38. Kimani Vidal, RB, Los Angeles Chargers

39. Stefon Diggs, WR, New England Patriots

40. Kyle Monangai, RB, Chicago Bears

*PPR Scoring

Sleeper Cheat Sheet, Week 10

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Seahawks Commanders Football
Seahawks QB Sam Darnold

Quarterback

1. Sam Darnold, Seattle Seahawks

2. J.J. McCarthy, Minnesota Vikings

3. Aaron Rodgers, Pittsburgh Steelers

4. Michael Penix Jr., Atlanta Falcons

5. Tua Tagovailoa, Miami Dolphins

Running Back

1. Dylan Sampson, Cleveland Browns

2. Devin Singletary, New York Giants

3. Tank Bigsby, Philadelphia Eagles

4. Bhayshul Tuten, Jacksonville Jaguars

5. Kenneth Gainwell, Pittsburgh Steelers

Wide Receiver

1. Alec Pierce, Indianapolis Colts

2. Troy Franklin, Denver Broncos

3. Christian Watson, Green Bay Packers

4. Parker Washington, Jacksonville Jaguars

5. Tez Johnson, Tampa Bay Buccaneers

Tight End

1. Colston Loveland, Chicago Bears

2. Harold Fannin Jr., Cleveland Browns

3. Theo Johnson, New York Giants

4. Dalton Schultz, Houston Texans

5. Mason Taylor, New York Jets

Deep Sleeper: Emari Demercado, RB, Arizona Cardinals

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Cardinals Cowboys Football

The Arizona Cardinals face a tough road game against a very good Seattle Seahawks defense. They'll do so with backup quarterback Jacoby Brissett behind center once again.

However, the news that Brissett will get another start should be welcomed by fantasy managers. The Cardinals offense has been much more efficient with him at quarterback than it was with Kyler Murray—Arizona has averaged a full five points per game more with Brissett at quarterback.

This also means that Emari Demercado is a viable deep sleeper in Week 10. Seattle has been more good than great against opposing running backs (11th-fewest fantasy points allowed), and Demercado's Week 9 performance may earn him additional opportunities.

Demercado averaged an impressive 5.6 yards per rush on a team-high 14 against the Dallas Cowboys last week. He's still available in over 80 percent of Yahoo and ESPN leagues.

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Deep Sleeper: Tory Horton, WR, Seattle Seahawks

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Seahawks Commanders Football

After largely disappearing for a few weeks, Seahawks rookie Tory Horton leapt back into the fantasy spotlight in Week 9. He caught four passes for 48 yards and two touchdowns in a blowout win over the Washington Commanders.

Cooper Kupp was inactive with a hamstring injury for that contest, and his status for Week 10 is still unclear. While Seattle did trade for Rashid Shaheed at the deadline, Horton may be in line for a significant role once again.

That's important because Horton has reached the end zone in four of his five games with a reception this season.

Against an underrated Cardinals defense, Horton is a total boom-or-bust play. However, he's available in over 80 percent of Yahoo and ESPN leagues and is worth a gamble in deeper leagues.

*Fantasy roster and scoring information from FantasyPros.

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