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INDIANAPOLIS, IN - NOVEMBER 30:  Andrew Luck #12 of the Indianapolis Colts looks to the bench during the game against the Washington Redskins at Lucas Oil Stadium on November 30, 2014 in Indianapolis, Indiana.  (Photo by Andy Lyons/Getty Images)
INDIANAPOLIS, IN - NOVEMBER 30: Andrew Luck #12 of the Indianapolis Colts looks to the bench during the game against the Washington Redskins at Lucas Oil Stadium on November 30, 2014 in Indianapolis, Indiana. (Photo by Andy Lyons/Getty Images)Andy Lyons/Getty Images

NFL Picks Week 15: Odds and Over-Under Advice Before Sunday Kickoff

Andrew GouldDec 14, 2014

Luckily only two teams play on Thursday night.

In yet another stinker on short rest, the Arizona Cardinals sleepwalked their way to an ugly victory over the St. Louis Rams. Neither team scored a touchdown during a defensive showdown that veered far below any reasonable over-under line.

With that clunker out of the way, let's turn to some more intriguing bouts, paying particular attention to two Super Bowl contenders led by prolific offenses. While one will light up the scoreboard against a favorable opponent, the other will have to employ a more reserved approach to avoid an upset.

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Pittsburgh Steelers at Atlanta FalconsPIT -3PIT55Over
Jacksonville Jaguars at Baltimore RavensBAL -13.5BAL45Under
Green Bay Packers at Buffalo BillsGB -4GB50Under
Tampa Bay Buccaneers at Carolina PanthersCAR -3TB41Over
Cincinnati Bengals at Cleveland BrownsCLE -1CIN44Under
Houston Texans at Indianapolis ColtsIND -7IND49Over
Oakland Raiders at Kansas City ChiefsKC -10OAK41.5Under
Miami Dolphins at New England PatriotsNE -7.5NE48Over
Washington Redskins at New York GiantsNYG -6.5NYG46.5Under
Denver Broncos at San Diego ChargersDEN -5DEN50.5Over
New York Jets at Tennessee TitansNYJ -3NYJ42Under
Minnesota Vikings at Detroit LionsDET -7.5MIN41.5Under
Seattle Seahawks at San Francisco 49ersSEA -9SEA38Under
Dallas Cowboys at Philadelphia EaglesPHI -3.5DAL55Over
New Orleans Saints at Chicago BearsNO -2.5NO54Over

Take the Over: Houston Texans at Indianapolis Colts (O/U 49)

HOUSTON, TX- OCTOBER 09: T.Y. Hilton #13 of the Indianapolis Colts is pushed out of bounds by Kendrick Lewis #21 of the Houston Texans in the third quarter in a NFL game on October 9, 2014 at NRG Stadium in Houston, Texas. (Photo by Bob Levey/Getty Images

The Indianapolis Colts can pass. The Houston Texans cannot stop the pass. 

Houston ranks No. 28 in yards allowed through the air, and Andrew Luck leads the league with 4,305 yards—an average of 331.2 per game. He continues his ascent to superstardom by shredding defenses deep, as highlighted by Pro Football Focus.

The math checked out during Week 6, when Luck compiled 370 passing yards and three touchdowns during a 33-28 victory. T.Y. Hilton especially had a day, rattling off 223 receiving yards and a score.

During his three years in the NFL, Hilton has routinely decimated Houston, posting 611 yards and six scores through five tilts.

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Averaging 31.3 points per game, the Colts should have little trouble hitting that mark against a matchup tailor-made to their strength. Don't assume a one-sided blowout, either.

The Colts relinquish 4.4 yards per carry, guiding Arian Foster to 109 rushing yards and two touchdowns when they last met. Ryan Fitzpatrick even authored 9.2 yards per passing attempt in a close loss.

Losing Andre Johnson—questionable to play due to a concussion—would sting a bit, as he tallied 99 yards and a touchdown in their earlier bout while DeAndre Hopkins was stymied to one catch.  

Meanwhile, Vontae Davis returned to practice after missing last week's game with a concussion of his own. That injury swing dampens Houston's chances of orchestrating an upset, but the Texans only need Foster and garbage-time passing in prevent defense to score 17-20 points while Indianapolis does the heavy lifting.

Take the Under: Green Bay Packers at Buffalo Bills (O/U 50)

ORCHARD PARK, NY - NOVEMBER 30:   Brian Hoyer #6 of the Cleveland Browns is sacked by Jerry Hughes #55 of the Buffalo Bills during the second half at Ralph Wilson Stadium on November 30, 2014 in Orchard Park, New York.  (Photo by Tom Szczerbowski/Getty Im

On the defensive end, the Buffalo Bills are for real.

A limited offense puts their playoff hopes in peril as they host the Green Bay Packers, who are riding a five-game winning streak atop the NFC North. Although containing MVP favorite Aaron Rodgers is a daunting task, Buffalo just muted another legend last weekend.

As the Denver Broncos continue their commitment to the run, Peyton Manning threw for a season-low 173 yards with no scores and two interceptions. According to ESPN Stats & Info, that marks his first game without a passing touchdown in quite some time.

Now Rodgers will try to combat the NFL's No. 5 passing defense, which leads the NFL with 48 sacks. He acknowledged the upcoming challenge to ESPN.com's Rob Demovsky.

Over Green Bay's winning streak, Rodgers has fired 16 passing touchdowns to zero interceptions. He has done so against three bottom-seven passing defenses (Chicago, Philadelphia, Atlanta), one middle-pack unit (New England) and the Minnesota Vikings' No. 6 group against the aerial attack.

When they last played the Vikings, the Packers attained a 24-21 victory by bottling Rodgers' usual assault for a run-heavy tactic. Rodgers settled for a 209-yard, two-touchdown game with Minnesota submitting only 308 total yards.

That's precisely the style of victory to anticipate here. Green Bay etches out a tough victory on the road but not with another monster offensive showing. Its defense showed vulnerability against the Falcons, but Buffalo doesn't boast the offensive firepower to exploit it for more than a low-20 point tally.

EPIC NFL Thanksgiving Slate 🙌

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