NFL Picks Week 1: Updated Outlook on Sunday's Odds and Spreads

Now that the defending Super Bowl champion Seattle Seahawks have gotten the season off to an explosive start with their 36-16 rout of the Green Bay Packers on Thursday, the rest of the NFL will try to keep pace on Sunday and Monday night.

The NFL season will kick into high gear on Sunday with a full slate of games and a Monday night doubleheader will follow.

Here's a look at the entire schedule as well as odds information for each matchup.

Sunday, September 7	Favorites/Odds	Location
Monday, September 8	Favorites/Odds	Location
New Orleans at Atlanta	New Orleans -2.5	Georgia Dome
Minnesota at St. Louis	St. Louis -3	Edward Jones Dome
Cleveland at Pittsburgh	Pittsburgh -7	Heinz Field
Jacksonville at Philadelphia	Philadelphia -11.5	Lincoln Financial Field
Oakland at NY Jets	N.Y. Jets -4.5	MetLife Stadium
Cincinnati at Baltimore	Baltimore -1	M&T Bank Stadium
Buffalo at Chicago	Chicago -4.5	Soldier Field
Washington at Houston	Even	Reliant Stadium
Tennessee at Kansas City	Kansas City -5.5	Arrowhead Stadium
New England at Miami	New England -1.5	Sun Life Stadium
Carolina at Tampa Bay	Carolina -3	Raymond James Stadium
San Francisco at Dallas	San Francisco -2.5	AT&T Stadium
Indianapolis at Denver	Denver -6	Sports Authority Field at Mile High
NY Giants at Detroit	Detroit -3.5	Ford Field
San Diego at Arizona	Arizona -3	U of Phoenix Stadium

Teams Most Likely to Cover

Philadelphia Eagles -11.5 over Jacksonville Jaguars

Al Bello/Getty Images

Double-digit deficits are hard to predict in the NFL, but if there's a game on the opening week schedule that screams blowout, it's the Jacksonville Jaguars trip to the City of Brotherly Love to take on the Philadelphia Eagles.

The biggest reason this game looks like such a mismatch is the matchup of the Eagles' rushing offense against the Jaguars' run defense.

Last season the Jags were ranked 29th in the NFL in run defense. While the team did add former Seahawks Red Bryant and Chris Clemons, it still doesn't figure to be able to handle Chip Kelly's offense and his dynamic running back LeSean McCoy. Philly was the league's best running team in 2013. 

It would be foolish to expect either of the teams to be drastically different than what they were last season.

Look for McCoy and Co. to wear down the Jags' defense with pace and big run plays. The Eagles will win by at least two touchdowns.

Chicago Bears -4.5 over Buffalo Bills

Jonathan Daniel/Getty Images

The Chicago Bears offense should be among the most potent in the NFL this season. Quarterback Jay Cutler is heading into his second season in head coach Marc Trestman's system. That's consistency and continuity that Cutler has never seen with the Bears.

Add into that mix a healthy complement of weapons in Brandon Marshall, Alshon Jeffery, Martellus Bennet, Matt Forte and a solid offensive line, and Cutler has what he needs to have a career year.

Buffalo will have serious issues keeping tabs on the Bears. Without safety Jairus Byrd, who left in free agency to join the New Orleans Saints in the offseason, the Bills' pass defense will experience a falloff this season.

Cutler and the Bears will take advantage in Week 1 with an offensive explosion. Buffalo simply doesn't have the firepower to keep pace. Chicago will win by 10.

New England Patriots -6.5 over Miami Dolphins

Charles Krupa/Associated Press

The New England Patriots should be near the top of everyone's short list of AFC Super Bowl contenders. With Rob Gronkowski expected to help energize the team's passing game and the addition of Darrelle Revis in the secondary, the Pats look primed for a great season.

Both Tom Brady and Gronkowski were listed as questionable for Sunday's game on Friday.

But based on Brady's comments, it seems unlikely that he will miss the game.

The team will be on the road in Week 1 against the Miami Dolphins but have the Fins really addressed their biggest issue from last season?

In 2013, quarterback Ryan Tannehill was sacked a league-high 58 times. New England recorded 10 of those sacks in the two games it played against Miami last year.

Because of the Pats' injury-ravaged wide receiver corps and other absences, they split the season series with Miami. The Dolphins did acquire Branden Albert and Samson Satele to bolster their O-Line, but it will take time for the unit to jell. During its transition, New England's defense will have success.

With a healthy team on both sides of the ball for Week 1, the Patriots will win on Sunday by two touchdowns.

All stats per Pro-Football-Reference.