Week 10 NFL Picks: Predicting Scores for Biggest Locks on Schedule

Rarely is there a sure thing in the NFL, but Week 10 does offer up some games where the favorites should be surefire locks to claim victory.

Two of those likely winners are jockeying for playoff position, while the other is seeking to sustain a stellar stretch by extending their winning streak to three games.

Read on to find out which teams are the surest bets to improve their respective records and continue building momentum through the second half of the pro football season.

Tennessee Titans over Jacksonville Jaguars

In an otherwise efficient Week 7 victory in St. Louis, Titans quarterback Jake Locker threw two interceptions.

The good news is that speedster running back Chris Johnson finally found his groove, rushing for 150 yards and two touchdowns. That was his best effort in a while to say the least:

Whether it was the bye week that set things right or established the proper chemistry with the offensive line is unclear, but if Johnson keeps running like that, the Titans are going to be a force to be reckoned with.

To Tennessee's delight, the winless Jacksonville Jaguars visit LP Field on Sunday, where the Titans can not only improve to 5-4 but also get a win within the AFC South.

No one allows more yards on the ground than Jacksonville's 161.8 per game, so if Johnson can keep the momentum going, it should be a field day for him.

The Titans are playing a physical brand of football this season, particularly on defense. Although they aren't statistically good against the run, they will dare Jags QB Chad Henne to beat them through the air and focus on stuffing Maurice Jones-Drew.

That has all signs pointing to Jacksonville dropping to 0-9, while Tennessee becomes perhaps the quietest team firmly fixed in the postseason picture.

Prediction: Titans 34, Jaguars 10

Indianapolis Colts over St. Louis Rams

Andrew Luck has been nothing short of spectacular in his first season and a half after being the No. 1 overall pick in the 2012 draft as successor to Peyton Manning in Indianapolis.

The signal-caller's progression in cutting down on interceptions in 2013 has been impressive:

However, the defining characteristic of Luck's game is how clutch he is in the fourth quarter.

Facing the Houston Texans' top-ranked pass defense last week, Luck shook off a putrid start to will his team to victory at Reliant Stadium and got a key win in the AFC South in the process.

Now the Colts return home to face the Rams, who have found a rookie fifth-round gem in Zac Stacy to set the tone as part of a physical running game. That is cause for concern, because Indianapolis has the league's 27th-ranked run defense.

The home team may be heavily favored, but this should be closer than the 10-point spread from Bovada would suggest.

At the end of the game, though, there are few quarterbacks who teams would trust more with the ball in their hands than Luck, and he will do enough to help the Colts. That's especially so when the opposing quarterback is Kellen Clemens.

Prediction: Colts 24, Rams 13

Philadelphia Eagles over Green Bay Packers

This would have been a laughable lock a week ago, but it goes to show just how much of a quarterback-driven league the NFL is.

Packers superstar QB Aaron Rodgers is out with a fractured collarbone, and his counterpart, Nick Foles, tied the NFL record with seven touchdown passes in last week's rout of the Oakland Raiders.

Suddenly, it seems head coach Chip Kelly's innovative, uptempo offense is a raging success at the professional level yet again.

As inconsistent as the Eagles have been, this is the perfect time for their league-worst pass defense to be cut a break against the likes of Seneca Wallace.

No matter how favorable the rules may tilt toward offenses in the modern day, Foles' performance can't be a mere fluke. Thus, look for the Eagles to air it out often and be able to keep the Pack honest enough with LeSean McCoy establishing the NFL's No. 1 rushing attack.

The result is a massive victory at Lambeau Field for Philadelphia and a potential tie with Dallas for the NFC East lead.

Prediction: Eagles 31, Packers 17

Away Team	Home Team	Winner
Washington Redskins	Minnesota Vikings	Redskins
Oakland Raiders	New York Giants	Giants
Seattle Seahawks	Atlanta Falcons	Seahawks
Detroit Lions	Chicago Bears	Lions
Philadelphia Eagles	Green Bay Packers	Eagles
Jacksonville Jaguars	Tennessee Titans	Titans
St. Louis Rams	Indianapolis Colts	Colts
Buffalo Bills	Pittsburgh Steelers	Steelers
Cincinnati Bengals	Baltimore Ravens	Bengals
Carolina Panthers	San Francisco 49ers	49ers
Houston Texans	Arizona Cardinals	Texans
Denver Broncos	San Diego Chargers	Chargers
Dallas Cowboys	New Orleans Saints	Saints
Miami Dolphins	Tampa Bay Buccaneers	Dolphins