Carolina Panthers vs. San Francisco 49ers: Spread Analysis and Pick Prediction

The San Francisco 49ers are 1-7 ATS lifetime at home against the Carolina Panthers, while the Panthers have covered 13 of their last 15 overall against San Francisco.

Carolina has proven to be a very dangerous road dog, while the Niners are 6-2 ATS in eight games as home chalk.

Point spread: 49ers opened as 6.5-point favorites; the total was 41.5. (Line updates and matchup report.)

Odds Shark computer prediction: 30.8-27.9 Panthers

Why the Panthers can cover the spread

There are many who believe the Panthers weren't even close to playing their best game in a win against the Atlanta Falcons last week. If that's the case, they better plan on bringing it to Frisco. Cam Newton was sloppy in the first half and can in fact play a much better game. He'll be at his best here.

The Panthers are 6-0 ATS in their past six as a road underdog, according to Odds Shark.

Why the 49ers can cover the spread

The San Francisco 49ers have won five games in a row and would love nothing more than to keep their momentum alive before meeting NFC West leaders the Seattle Seahawks for a second time this season.

Colin Kaepernick looks as if he's just warming up. Back at home after a game in London, he should be at ease.

Smart Pick

While everyone continues to underestimate the Panthers, it's time to start taking them seriously. They've proven they're more than just Newton at quarterback.

Carolina went into last week averaging 130 yards rushing per game. On Sunday, the team had 131 yards rushing on 33 carries. A balanced attack keeps this close.

Trends

49ers OVER is 12-1 past 13 seasons after a bye week

Carolina 13-2 ATS past 15 games versus 49ers

OVER is 12-2 past 14 meetings

49ers 1-7 ATS lifetime at home versus Panthers

Panthers 6-0 ATS past six games as road underdog

Niners are 6-2 ATS past eight games as home chalk

Note: All spread and odds data powered by Odds Shark. Follow them on Twitter for injury updates and line move updates.