Colts vs. 49ers: TV Info, Spread, Injury Updates, Game Time and More

The Indianapolis Colts and San Francisco 49ers are two teams in similar situations entering Week 3 after disappointing showings in defeat a week ago, dropping their records to 1-1.

Now the two are set for a date at Candlestick Park in one of the week's more intriguing matchups.

San Francisco entered the season looking like the team that made it to the Super Bowl last year by beating up on Green Bay, but subsequently traveled to Seattle last week and was blown out of the water.

Things have not been as encouraging in Indianapolis. The Colts survived a scare at home from Oakland before being upset by Miami, while the defense had serious issues containing an explosive offense.

The Colts recently sent shock waves through the league after trading for Trent Richardson. While the long-term future of Richardson in Indianapolis is bright, he'll undoubtedly still be getting acclimated to the offense this week. It will be interesting to see how active of a role he plays in his first game as a Colt, though his matchup against the 49ers run defense isn't exactly favorable.

The 49ers made news of their own this week, as Aldon Smith was arrested for a DUI and marijuana possession on September 20. Smith will play Sunday, though it remains unclear as to what action the NFL will take going forward.

Both teams need a rebound performance to remain competitive in their respective divisions. There's a lot riding on the shoulders of young quarterbacks Andrew Luck and Colin Kaepernick.

Here is a full breakdown of the contest.

When: Sunday, Sept. 22, at 4:25 p.m. ET

Where: Candlestick Park, San Francisco, CA.

Watch: CBS

Live Stream: NFL Sunday Ticket

Betting Lines (via Bovada)

• Over/Under: 47 pts
• Spread: San Francisco (-10)

Colts Injury Report (via NFL.com) 

Cory Redding	DE	Back	Did Not Participate in Practice	Questionable
LaRon Landry	S	Ankle	Did Not Participate in Practice	Out
T.Y. Hilton	WR	Groin	Limited Participation in Practice	Probable
Kavell Conner	LB	Ankle	Full Participation in Practice	Probable
Pat Angerer	LB	Knee	Did Not Participate in Practice	Doubtful
Samson Satele	C	Elbow	Did Not Participate in Practice	Questionable
Antoine Bethea	S	Toe	Limited Participation in Practice	Questionable
Darrius Heyward-Bey	WR	Ribs	Full Participation in Practice	Probable
Dwayne Allen	TE	--	Did Not Participate in Practice	--
Reggie Wayne	WR	Shoulder	Full Participation in Practice	Probable
David Reed	WR	Quadriceps	Full Participation in Practice	Probable

49ers Injury Report (via NFL.com) 

Justin Smith	DT	Shoulder	Limited Participation in Practice	Probable
Mike Iupati	G	Shoulder	Full Participation in Practice	Probable
Eric Reid	S	Concussion	Limited Participation in Practice	Questionable
Aldon Smith	LB	Back	Limited Participation in Practice	Probable
Vernon Davis	TE	Hamstring	Did Not Participate in Practice	Questionable
Ray McDonald	DT	Ankle	Limited Participation in Practice	Questionable
LaMichael James	RB	Knee	Limited Participation in Practice	Questionable
NaVorro Bowman	LB	Wrist	Limited Participation in Practice	Probable
Colin Kaepernick	QB	Foot	Full Participation in Practice	Probable

  

Can the Colts Contain Colin Kaepernick?

Above is a question NFL fans are going to ask for a very long time. It was partially answered last week as the Seattle Seahawks held Kaepernick to 214 total yards and no scores. That certainly won't be the case every week, as witnessed in Week 1 when Kaepernick torched Green Bay for 412 yards and three scores through the air.

The task now falls to a Colts defense that mightily struggled against an athlete similar to Kaepernick in Week 1. While the Raiders' Terrelle Pryor is nowhere near the passer Kaepernick is, Pryor has the ability to beat defenses with his feet.

Pryor compiled 329 total yards and one touchdown in a losing effort. The problem here is simple: Kaepernick is twice the player Pryor is, and the 49ers have a major advantage in the talent department when compared to Oakland.

After a down week, Kaepernick and Co. are sure to come out firing using the blueprint laid down by the Raiders two weeks ago. How the Colts defense responds, led by free-agent acquisition LaRon Landry, will decide the outcome.

Prediction

Jim Harbaugh may have loved Andrew Luck back at Stanford, but now he's got another favorite quarterback in Kaepernick, who is surrounded by a vastly superior San Francisco squad when compared to the Colts.

At home after a physical loss, the 49ers are going to be tough to defeat. The Colts simply don't have the man power to compete with the physicality and depth San Francisco brings to the table.

Luck has an outside chance of overcoming the 49ers if Frank Gore and Co. struggle to run the ball effectively, but that should not be a cause for concern against a defense that ranks 29th against the run.

Kaepernick and Co. score a major bounce-back victory at home.

Final Score 

49ers win 38-21

Follow B/R's Chris Roling on Twitter for more news and analysis @Chris_Roling