NFL Picks Week 6: Guaranteed Winners You Would Be Crazy Not to Bet

Vegas has set some pretty tight lines for us in Week 6 of the NFL season, but there are still a few locks to bet big on Sunday.

These teams have proven they are legitimate this season and have been covering nearly every spread that bookmakers are throwing their way.

Let’s take a look at the three biggest locks that will definitely cover the spread in Week 6.

New England Patriots -7 vs. Dallas Cowboys

The Patriots host the Cowboys this Sunday and are only laying seven points.

You have to make this play, because the Patriots have proven time and time again that they are the best team in the league at home, and the Cowboys are in the midst of a meltdown.

Romo has been playing poorly, and he may even struggle against the worst secondary in the league. There is no way you can ride the Cowboys even getting seven in Foxboro.

New Orleans Saints -4.5 at Tampa Bay Buccaneers

Love the top team in the division giving only 4.5-points to potentially the worst squad in the NFC South.

The Saints aren’t playing at home, but Raymond James isn’t exactly a nightmare to play in and they aren’t traveling very far.

After seeing the Niners blow out the Bucs, I expect the Saints to absolutely crush them and continue their stranglehold on the division. Lay the points here.

Detroit Lions -4.5 vs. San Francisco 49ers

Detroit is legit. They are 5-0 for a reason, and Matthew Stafford and Calvin Johnson are going to have the Lions back in the playoffs for the first time since 1999.

Ford Field has become a great place to play again, and the home crowd is rocking each and every game.

Both of these teams are 4-0-1 ATS so far, but the 49ers are going to take their first loss this season and lose by at least a touchdown.

There is no way they can contain the Lions’ powerful offense and devastating defense.