NFL Predictions Week 5: LeGarrette Blount and 4 RBs Due for Huge Games

While the 49ers have improved their front seven despite the loss of nose tackle Aubrayo Franklin, LaGarrette Blount has emerged as one of the most physical and difficult backs to bring down. He runs behind a line that is built to run the football (although they have struggled in pass protection). 

Another back that will have a lot of success in Week 5 is LeSean McCoy. McCoy might be the shiftiest back in the NFL, and he goes against an improved, but still very average run defense in Buffalo.

Talented rookie Danny Watkins, who has been sitting on the bench while adjusting to the pro game, will get the start. If Watkins plays as well as he can, he can be a huge boost in the run game for the Eagles. 

Look for Ryan Mathews to have a career day against the Broncos this week.

Denver has struggled to stop the run, and Mathews is looking more and more like the talented back he was drafted to be. He is gradually taking away more and more carries away from Mike Tolbert as the season wears on.

With Philip Rivers not quite looking like the same guy so far this season, the Chargers may run the ball more than they usually do.  

Finally, expect Darren McFadden of the Raiders to run all over the Houston Texans.

The Texans defense is much improved from last season, but McFadden seems to have huge days against even the stingiest of run defenses. If the Texans don't set their edges and play disciplined, McFadden is going to break a couple of long runs.