NFL Week 4 Picks: Upcoming Odds and Predictions for Full Schedule

The Buffalo Bills enter Week 4 among the six NFL teams on top of their divisions with undefeated records.

Sean McDermott's team put together two comebacks against the Miami Dolphins and Los Angeles Rams to remain perfect. Their toughest challenge yet could come Sunday at Allegiant Stadium in a showdown with the Las Vegas Raiders, who will be trying to rebound from a double-digit loss to another AFC East side in Week 3.

The Bills could be in line for another high point total, but they may not eclipse the offensive production of the Seattle Seahawks. Seattle's matchup with the Miami Dolphins is one of a few with an over/under line set in the 50s. Given the nature of Seattle's first three games, the over appears to be a safe wager.

NFL Week 4 Schedule and Odds

Thursday, October 1

Denver (-2.5) at New York Jets (8:20 p.m., NFL Network) (Over/Under: 40)

Sunday, October 4

Baltimore (-13.5) at Washington (1 p.m., CBS)

Indianapolis (-2.5) at Chicago (1 p.m., CBS) (O/U: 44.5)

Jacksonville at Cincinnati (-3) (1 p.m., CBS) (O/U: 44.5)

Los Angeles Chargers at Tampa Bay (-7) (1 p.m., CBS) (O/U: 45)

Pittsburgh at Tennessee (-1.5) (1 p.m., CBS) (O/U: 47.5)

Arizona (-4) at Carolina (1 p.m., Fox) (O/U: 51.5)

Cleveland at Dallas (-5.5) (1 p.m., Fox) (O/U: 55.5)

Minnesota at Houston (-4) (1 p.m., Fox) (O/U: 51.5)

New Orleans (-3.5) at Detroit (1 p.m., Fox)

Seattle (-7) at Miami (1 p.m., Fox) (O/U: 54.5)

New York Giants at Los Angeles Rams (-11.5) (4:05 p.m., Fox) (O/U: 48)

New England at Kansas City (-7) (4:25 p.m., CBS)

Buffalo (-2.5) at Las Vegas (4:25 p.m., CBS) (O/U: 49.5)

Philadelphia at San Francisco (-6) (8:20 p.m., NBC) (O/U: 43)

Monday, October 5

Atlanta at Green Bay (-7) (8:15 p.m., ESPN)

All Times ET; odds via DraftKings Sportsbook.

Predictions

Buffalo (-2.5) at Las Vegas

Buffalo's offense has received a majority of the spotlight in recent weeks because of the nature of their victories.

However, the difference-making quality in the Bills team Sunday could be their rushing defense.

Buffalo has allowed 106 rushing yards per game, which is the ninth-best total in the NFL. If the Bills slow down Josh Jacobs, they will take away a key aspect of the Las Vegas offense. Jacobs was held to his lowest rushing total of the season in Week 3 against the New England Patriots, who allow 12 more ground yards per contest than the Bills.

Las Vegas also struggled to hold on to the ball against the Patriots, with three turnovers off fumbles. Buffalo has two forced fumbles and a pair of interceptions.

If Matt Milano and Tremaine Edmunds crowd the box and smother Jacobs' production, it could force the Raiders into long third-down situations. Buffalo could have the advantage in those scenarios as well, with Tre'Davious White locked in on Las Vegas' top wide receiver.

If the Bills defense flips the field in the offense's favor, quarterback Josh Allen could take over and avoid having to make another fourth-quarter comeback.

Allen has 1,038 passing yards, 10 touchdowns and one interception, as well as 84 rushing yards and a pair of scores. His primary passing focus has been on Stefon Diggs, who has added a new dimension to the Buffalo offense.

Diggs has brought in 20 of his 28 targets for a team-high 288 yards. If he and Allen on the same page early, it could put the Raiders in a hole they can't get out of.

Seattle at Miami (Over 54.5)

Each of Seattle's three games this season has featured more than 60 points.

The Russell Wilson-led offense produced at least 35 points in each of those contests.

Wilson already has 14 passing touchdowns and has a pair of 200-yard wide receivers in DK Metcalf and Tyler Lockett.

The Seahawks could torch Miami's secondary in a similar manner as Buffalo did in Week 2, when the Bills put up 411 passing yards.

Miami ranks eighth in passing yards conceded per game, a category that is topped by Seattle after playing Matt Ryan, Cam Newton and Dak Prescott.

If Ryan Fitzpatrick takes advantage of the holes in the Seattle secondary, he could match Wilson's pace for at least a half. In his past four home games, Fitzpatrick has thrown for more than 300 yards and added nine passing touchdowns.

The one concern with Fitzpatrick is his potential to turn over the ball. He had three interceptions in a 21-11 loss to New England in Week 1. If the Dolphins quarterback remains clean in the pocket, he could aid a growing point total and add to the Seattle over trend.

Follow Joe on Twitter, @JTansey90. Statistics obtained from ESPN.com.