NFL Week 2 Picks: Final Predictions and Over-Under Odds Before Thursday Night

Zach Buckley@@ZachBuckleyNBANational NBA Featured ColumnistSeptember 17, 2020

Arizona Cardinals quarterback Kyler Murray (1) passes against the San Francisco 49ers during the first half of an NFL football game in Santa Clara, Calif., Sunday, Sept. 13, 2020. (AP Photo/Josie Lepe)
Josie Lepe/Associated Press

Bettors of the world, how are your wallets looking after Week 1 of the 2020 NFL season?

If you backed the Baltimore Ravens and New Orleans Saints, they should be in great shape. But if you went big on the San Francisco 49ers and Tampa Bay Buccaneers, then not so much.

Another week brings another round of money-making opportunities, though, so let's not waste any more time celebrating our victories or lamenting our defeats. Instead, let's get to the latest lines from DraftKings, provide a score prediction for each contest and lay out three of our strongest hunches.


NFL Week 2 Point Spreads and Over/Under Totals

Cincinnati Bengals at Cleveland Browns (-6) | O/U 43

San Francisco 49ers (-7) at New York Jets | O/U 42.5

Buffalo Bills (-5.5) at Miami Dolphin | O/U 41

Video Play Button
Videos you might like

Detroit Lions at Green Bay Packers (-6.5) | O/U 49.5

Denver Broncos at Pittsburgh Steelers (-7.5) | O/U 41.5

Carolina Panthers at Tampa Bay Buccaneers (-9.5) | O/U 48.5

Minnesota Vikings at Indianapolis Colts (-3) | O/U 48

Jacksonville Jaguars at Tennessee Titans (-9) | O/U 42

Los Angeles Rams (-1) at Philadelphia Eagles | O/U 45.5

Atlanta Falcons at Dallas Cowboys (-4.5) | O/U 53

New York Giants at Chicago Bears (-5.5) | O/U 42.5

Washington at Arizona Cardinals (-6.5) | O/U 46.5

Kansas City Chiefs (-8.5) at Los Angeles Chargers | O/U 47.5

Baltimore Ravens (-7) at Houston Texans | O/U 52

New England Patriots at Seattle Seahawks (-4) | O/U 45

New Orleans Saints (-6) at Las Vegas Raiders | O/U 50.5


Week 2 Score Predictions

Bengals 23, Browns 20

49ers 28, Jets 10

Bills 21, Dolphins 16

Packers 24, Lions 20

Steelers 28, Broncos 42

Buccaneers 31, Panthers 24

Vikings 24, Colts 21

Titans 24, Jaguars 13

Rams 27, Eagles 24

Cowboys 34, Falcons 27

Giants 20, Bears 14

Cardinals 31, Washington 10

Chiefs 28, Chargers 20

Ravens 34, Texans 27

Seahawks 29, Patriots 20

Saints 34, Raiders 24


Strongest Hunches for Week 2

49ers Will Cover With Ease

The 49ers certainly didn't look like the 13-win, defending NFC champions in their Week 1 loss to the Cardinals. This is their chance to correct that.

The Jets are not good. Their 27-17 loss to the Bills was even more lopsided than it sounds. New York's first points didn't come until there were three seconds left in the first half. By that point, Buffalo already had 21 points on the board. The Bills basically went into cruise control from there, and even then, they had a 17-point advantage before the Jets scored in the game's final minute.

This has get-right game written all over it for San Francisco. Its defense had trouble with a mobile quarterback in Kyler Murray and an elite receiver in DeAndre Hopkins. New York has none of those things. Its offense featured a rusty-looking Jimmy Garoppolo (57.6 completion percentage). He'll get another week to find his rhythm then face a pass defense that no longer has Jamal Adams protecting its back end.

The Niners might not win the NFC again. Most Super Bowl losers don't get a chance to avenge their loss. But this team can and should roll over New York by a double-digit margin.


Cowboys and Falcons Will Blow Past the Over

If folks in Atlanta listen closely enough, they can still hear the fireworks from Sunday's 38-25 loss to the Seahawks. The game was basically a master class in aerial attacking, as Matt Ryan threw for 450 yards, and Russell Wilson went for 322 with the same number of incompletions and touchdowns (four each).

The fireworks were more subdued in the Cowboys' 20-17 loss to the Rams. Dak Prescott threw the game's only touchdown pass. Just 10 points were scored after halftime, but the two clubs combined for more than 800 yards of offense.

In other words, Dallas has the firepower to put a huge number in the scoring column, even if it didn't do that Sunday night. Atlanta has the explosive offense and leaky defense to find itself in high-scoring shootouts from week-to-week.

While 53 points is a healthy number—the highest over/under for Week 2—it still feels short of what these teams will ultimately post. When you can feel comfortable banking on at least 700 passing yards from the two quarterbacks, you're probably headed toward a total score in the 60s.


Cardinals Will Cruise to Double-Digit Victory

So, maybe we should've seen this coming, but the Murray-Hopkins connection has a chance to be special.

Granted, Hopkins could probably look good with any passer, but his Cardinals debut was ridiculous even by his standards. He turned his 16 targets into 14 receptions for 151 yards. The 14 catches were a new career-high, and the 151 yards matched his seventh-highest game total.

"We can be great," Murray told reporters. "I know we both have aspirations of being the best to do it. So that's where I hope to take this thing. We don't step into the building every day and try to get worse. We try to be the best that we can be. I'm glad that he's on our team."

Arizona seems like the kind of club that could dramatically outperform expectations. What that means for gamblers is it's time to go heavy on this team before oddsmakers figure out how good it is.