He was ruled out for the remainder of the game as the Niners took a 27-0 lead into halftime.
Overall in 2019, Coleman ran for 544 yards and six touchdowns in 14 games, adding 21 receptions for 180 yards and a score.
He joined San Francisco on a two-year, $10 million contract before this season after he began his career with the Atlanta Falcons, playing there from 2015 to 2018. Last year, he appeared in all 16 games (14 starts). He rushed 167 times for 800 yards and four touchdowns, and caught 32 passes for 276 yards and five touchdowns.
Coleman saw increased production as a primary back last season because Devonta Freeman, the team's regular No. 1, missed all but two games. Freeman had been nagged by a knee injury and foot problem before he landed on injured reserve for a groin injury on Oct. 16.
Overall in Atlanta behind Freeman, Coleman totaled 2,340 yards and 18 touchdowns as a rusher as well as 1,010 yards and 11 touchdowns as a receiver.
Should Coleman remain sidelined, San Francisco will likely lean more heavily upon Raheem Mostert, who scored a touchdown in the first quarter.