Real Madrid were unable to prevent Barcelona from continuing their unbeaten run in La Liga on Sunday as the Clasico at the Camp Nou ended in a 2-2 draw.
Los Blancos still have three games to play in the Spanish top flight this season, and the first is against Sevilla on Wednesday.
Given Real have a UEFA Champions League final against Liverpool coming up on May 26, it seems likely manager Zinedine Zidane will play a weakened side at the Ramon Sanchez Pizjuan Stadium.
But there is still the incentive of potentially pipping Atletico Madrid to second, while Sevilla will surely be looking to secure a marquee result to close out a disappointing domestic season.
Date: Wednesday, May 9
Time: 8:30 p.m. BST, 3:30 p.m. ET
TV Info: Sky Sports Mix (UK), beIN Sports (U.S.)
The reverse fixture between Real and Sevilla at the Santiago Bernabeu in December saw Los Blancos run out 5-0 winners.
On that occasion Cristiano Ronaldo netted twice, but the Portuguese star is set to be absent for Wednesday's clash, per Tomas Roncero of AS.
Real also didn't have their biggest game of the season on the horizon back in December.
No matter the professionalism and quality of Real's players there is little doubt they will have the Champions League final in the back of their minds in their closing La Liga games.
Players will be desperate not to pick up an injury that could rule them out of the Liverpool clash at Kiev's NSC Olimpiyskiy Stadium.
Zidane could opt to play a reserve side against Sevilla in the hope they will play to 100 per cent in an attempt to earn a spot in the final.
However, he does not want his star men to be under-played when they travel to the Ukraine at the end of this month.
Circumstances could combine to give Sevilla a great chance of victory on Wednesday.
They ended a run of nine games without a victory in all competitions by beating Real Sociedad 1-0 last time out so will be buoyed going into Wednesday's fixture.
A lot will depend on Zidane's selection, but Sevilla have realistic ambitions of picking up all three points against Real.