A statement on United's official website hinted that further fixtures will be announced. But clashes against Mexican side Club America at the University of Phoenix Stadium, Arizona, and MLS outfit San Jose Earthquakes at Levi's Stadium in Santa Clara, California, have been confirmed.
The Club America fixture is scheduled for Thursday, July 19 at 7 p.m. local time, while the San Jose match will kick off at 2 p.m. local time on Sunday, July 22.
United have been regular visitors to the U.S. in recent years. Last summer Jose Mourinho's men travelled stateside to take on Manchester City, Barcelona and Real Madrid in the 2017 International Champions Cup.
The Red Devils will have plenty to work on in their pre-season tour ahead of the 2018-19 campaign.
The best they can hope to finish with in the 2017-18 season is the FA Cup and second place in the Premier League.
While that would be a decent return for most clubs, it will be regarded as disappointing by United.
During their U.S. tour, they will be looking to make preparations to close the gap to Premier League champions-elect Manchester City.