New England Patriots vs. San Francisco 49ers Betting Odds, Analysis, NFL Pick

The New England Patriots (7-2) will look to bounce back from their second loss of the season when they visit the San Francisco 49ers (1-8) on Sunday as double-digit road favorites. The Patriots are a perfect 4-0 straight up and against the spread this year on the road, while the 49ers have lost eight straight games.

Point spread: The Patriots opened as 14-point favorites; the total was 51.5 early in the week, according to sportsbooks monitored by Odds Shark (line updates and matchup report).

NFL pick, via Odds Shark computer: 34.9-16.9 Patriots (NFL picks on every game)

Why the Patriots can cover the spread

New England, which GambleOnline.co noted is the Super Bowl 51 favorite, is playing its second consecutive NFC West opponent after falling to the Seattle Seahawks 31-24 as 7.5-point home chalk in the Week 10 Sunday night matchup.

The Patriots are 16-3 straight up in their last 19 games following a loss and 4-1 against the spread the past five times after losing the previous matchup in a series. The teams last met in 2012 at Gillette Stadium, with San Francisco winning 41-34 as 3.5-point road dogs.

But the 49ers are a much different team now, and Tom Brady and his teammates will certainly be looking to take out their frustrations this week away from home off the Seattle loss.

Why the 49ers can cover the spread

The 49ers have surprisingly won seven of the past 10 meetings with New England SU, although they do not play each other often. San Francisco's lone win this season came at home back in Week 1, and motivation should be high considering this is the team's Super Bowl in a sense.

In the last meeting four years ago, quarterback Colin Kaepernick helped the 49ers hold off the Patriots with four touchdown passes, while Brady threw for 443 yards but was picked off twice en route to a loss. New England seems to have trouble with running quarterbacks, as Russell Wilson of the Seahawks and Tyrod Taylor of the Buffalo Bills are the only two to beat them this season.

Smart pick

It's hard to go against Brady and Co. in this spot. He will be playing the team he grew up rooting for, which is just 1-7 ATS during its skid. The Patriots have covered the spread in three of the past four meetings, including the loss in the last one, and should have no problem winning by more than two touchdowns in another road rout.

Betting trends

The Patriots are 3-1 ATS in their last four games against the 49ers.

The 49ers are 0-8 SU and 1-7 ATS in their last eight games.

The total has gone under in seven of the 49ers' last nine games as home underdogs.

All NFL betting lines and point spreads data courtesy of Bleacher Report’s official odds partner, Odds Shark. All quotes gathered firsthand unless otherwise noted. Check out Twitter for injury and line movement updates and Odds Shark YouTube for picks and analysis, or download the free odds tracker app.