The San Francisco 49ers, with a record of 2-1, looked to be the team to beat in the NFC West after the first three weeks of the season.
Those two wins were thanks in large part to big games by the 49ers' former All-Pro running back, Frank Gore. After his first carry of Week Three, Gore was injured and San Francisco went on to lose its first game of the season. The Niners may have to get used to his absence for a little while longer.
According to reports, Gore will miss up to three weeks with a right angle sprain.
After the final-second loss to Brett Favre and the Vikings, the team is going to adjust the offensive play calling for the next few weeks with their star running back out.
San Francisco could hold their division lead in Gore's absence, as the next three games will not be played against any of the top-tier defenses in the league.
The 49ers face a division foe in the St. Louis Rams, followed by the Atlanta Falcons and the Houston Texans.
Matt Miselis is a writer for BleacherReport.com