The Serb represented the Red Devils 300 times between 2006 and 2014, winning five Premier League titles and a UEFA Champions League along the way.
In a statement released on United's official website, Vidic said:
The time has come for me to hang up my boots. The injuries I have had in the last few years have taken their toll.
I would like to thank all the players I have played with, all the managers and staff I have worked with, and say a big 'thank you' to the fans for their support over the years.
The footballing community was quick to pay tribute to the 34-year-old:
As were his fans:
There was the occasional joke about why he might have picked now as a good time to call it quits...
...though most chose to remember his iconic partnership with former England international Rio Ferdinand.
There was plenty of reminiscing about Vidic's best days in a United shirt.
And many wondered what Louis van Gaal would do to have a leader like Vidic in his side today.